BRD-K83963101_MLN-8054_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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98 genes differentially expressed following the BRD-K83963101_MLN-8054_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM12 ADAM metallopeptidase domain 12
AHR aryl hydrocarbon receptor
ASS1 argininosuccinate synthase 1
CALB1 calbindin 1, 28kDa
CDK17 cyclin-dependent kinase 17
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLEC11A C-type lectin domain family 11, member A
CNOT2 CCR4-NOT transcription complex, subunit 2
COBL cordon-bleu WH2 repeat protein
CRY1 cryptochrome circadian clock 1
CTSW cathepsin W
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DLC1 DLC1 Rho GTPase activating protein
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM129A family with sequence similarity 129, member A
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HOMER1 homer scaffolding protein 1
HOXC6 homeobox C6
IL6 interleukin 6
LDLR low density lipoprotein receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
LY75 lymphocyte antigen 75
MAOA monoamine oxidase A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRNP prion protein
SACS sacsin molecular chaperone
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SNAP25 synaptosomal-associated protein, 25kDa
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC1 stanniocalcin 1
TEX10 testis expressed 10
TSC22D1 TSC22 domain family, member 1
VDAC1 voltage-dependent anion channel 1

decreased expression

Symbol Name
ABI1 abl-interactor 1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
BST2 bone marrow stromal cell antigen 2
CD24 CD24 molecule
CDC42 cell division cycle 42
CELF2 CUGBP, Elav-like family member 2
CORO1A coronin, actin binding protein, 1A
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DSP desmoplakin
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EMX2 empty spiracles homeobox 2
GDI2 GDP dissociation inhibitor 2
GLO1 glyoxalase I
GLUL glutamate-ammonia ligase
GSTT1 glutathione S-transferase theta 1
HNMT histamine N-methyltransferase
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
KIF5B kinesin family member 5B
LARP4B La ribonucleoprotein domain family, member 4B
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSRB2 methionine sulfoxide reductase B2
MTPAP mitochondrial poly(A) polymerase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
OPTN optineurin
PARD3 par-3 family cell polarity regulator
PFKP phosphofructokinase, platelet
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RNASE4 ribonuclease, RNase A family, 4
SEPP1 selenoprotein P, plasma, 1
SFTPA2 surfactant protein A2
TFF3 trefoil factor 3 (intestinal)
TKT transketolase
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
WAC WW domain containing adaptor with coiled-coil
WNT5A wingless-type MMTV integration site family, member 5A
YME1L1 YME1-like 1 ATPase