BRD-K83972459_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K83972459_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
AFF1 AF4/FMR2 family, member 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD10 ankyrin repeat domain 10
ARID4B AT rich interactive domain 4B (RBP1-like)
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNG2 cyclin G2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLCA2 chloride channel accessory 2
CLU clusterin
FDFT1 farnesyl-diphosphate farnesyltransferase 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GOLGA8A golgin A8 family, member A
GRN granulin
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRS2 insulin receptor substrate 2
KDM5A lysine (K)-specific demethylase 5A
LAMP2 lysosomal-associated membrane protein 2
LIMCH1 LIM and calponin homology domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MSMO1 methylsterol monooxygenase 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEB nebulin
PILRB paired immunoglobin-like type 2 receptor beta
RAB4A RAB4A, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RSRP1 arginine/serine-rich protein 1
SC5D sterol-C5-desaturase
SCGB2A2 secretoglobin, family 2A, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SIK3 SIK family kinase 3
SQLE squalene epoxidase
STXBP1 syntaxin binding protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TM7SF2 transmembrane 7 superfamily member 2
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UGCG UDP-glucose ceramide glucosyltransferase
WDR37 WD repeat domain 37
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA4 annexin A4
BZW2 basic leucine zipper and W2 domains 2
CCDC86 coiled-coil domain containing 86
DCK deoxycytidine kinase
EVI2A ecotropic viral integration site 2A
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GPX2 glutathione peroxidase 2
GSTO1 glutathione S-transferase omega 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ISOC1 isochorismatase domain containing 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MCTP1 multiple C2 domains, transmembrane 1
MXRA5 matrix-remodelling associated 5
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRR7 proline rich 7 (synaptic)
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF2 trefoil factor 2
TMC5 transmembrane channel-like 5
VCAN versican
Funding