BRD-K83972459_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

212 genes differentially expressed following the BRD-K83972459_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
ARL4C ADP-ribosylation factor-like 4C
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD2 bromodomain containing 2
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCN3 chloride channel, voltage-sensitive 3
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
CTH cystathionine gamma-lyase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSC3 desmocollin 3
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
FBXO21 F-box protein 21
FBXW2 F-box and WD repeat domain containing 2
FLNA filamin A, alpha
FN1 fibronectin 1
FOXN3 forkhead box N3
FOXO3 forkhead box O3
FSD1 fibronectin type III and SPRY domain containing 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GLS glutaminase
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSDMB gasdermin B
GSTA4 glutathione S-transferase alpha 4
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
JAG1 jagged 1
JUNB jun B proto-oncogene
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDM3A lysine (K)-specific demethylase 3A
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
LCK LCK proto-oncogene, Src family tyrosine kinase
LGMN legumain
LPIN1 lipin 1
LRP4 low density lipoprotein receptor-related protein 4
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKRN1 makorin ring finger protein 1
MN1 meningioma (disrupted in balanced translocation) 1
MSN moesin
MTSS1 metastasis suppressor 1
NCAM1 neural cell adhesion molecule 1
NDN necdin, melanoma antigen (MAGE) family member
NEB nebulin
NLRP2 NLR family, pyrin domain containing 2
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PBX3 pre-B-cell leukemia homeobox 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLD3 phospholipase D family, member 3
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPAP2B phosphatidic acid phosphatase type 2B
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTCH1 patched 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SIDT2 SID1 transmembrane family, member 2
SIK1 salt-inducible kinase 1
SORBS1 sorbin and SH3 domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STXBP1 syntaxin binding protein 1
SULF1 sulfatase 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
TST thiosulfate sulfurtransferase (rhodanese)
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNC13B unc-13 homolog B (C. elegans)
VIM vimentin
YPEL5 yippee-like 5 (Drosophila)
ZCCHC14 zinc finger, CCHC domain containing 14
ZNF331 zinc finger protein 331
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ATF1 activating transcription factor 1
B3GNT1
C2CD2 C2 calcium-dependent domain containing 2
CCL19 chemokine (C-C motif) ligand 19
CD58 CD58 molecule
CHL1 cell adhesion molecule L1-like
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CTPS2 CTP synthase 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
EREG epiregulin
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FHL2 four and a half LIM domains 2
FLT3 fms-related tyrosine kinase 3
FTO fat mass and obesity associated
GABPB1 GA binding protein transcription factor, beta subunit 1
HBD hemoglobin, delta
ICT1 immature colon carcinoma transcript 1
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
LAT2 linker for activation of T cells family, member 2
LOC100505650 uncharacterized LOC100505650
MCM5 minichromosome maintenance complex component 5
NR2F6 nuclear receptor subfamily 2, group F, member 6
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP85 nucleoporin 85kDa
OBSL1 obscurin-like 1
PARP2 poly (ADP-ribose) polymerase 2
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRR7 proline rich 7 (synaptic)
RFC3 replication factor C (activator 1) 3, 38kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SHCBP1 SHC SH2-domain binding protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNGR1 synaptogyrin 1
TBX2 T-box 2
TCERG1 transcription elongation regulator 1
TFPI2 tissue factor pathway inhibitor 2
TIPIN TIMELESS interacting protein
TMEM109 transmembrane protein 109
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
Funding