BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALB albumin
ASGR2 asialoglycoprotein receptor 2
ASPN asporin
ATF3 activating transcription factor 3
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLC Charcot-Leyden crystal galectin
CLCA4 chloride channel accessory 4
COL1A2 collagen, type I, alpha 2
DDIT4 DNA-damage-inducible transcript 4
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
FABP1 fatty acid binding protein 1, liver
FRY furry homolog (Drosophila)
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HBD hemoglobin, delta
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGKV4-1 immunoglobulin kappa variable 4-1
JAG1 jagged 1
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LAMP5 lysosomal-associated membrane protein family, member 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
METTL7A methyltransferase like 7A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLVAP plasmalemma vesicle associated protein
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
SERINC5 serine incorporator 5
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STC1 stanniocalcin 1
TCF4 transcription factor 4
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABLIM1 actin binding LIM protein 1
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
AK2 adenylate kinase 2
AKAP1 A kinase (PRKA) anchor protein 1
AKAP10 A kinase (PRKA) anchor protein 10
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
AP5M1 adaptor-related protein complex 5, mu 1 subunit
AQP3 aquaporin 3 (Gill blood group)
ARFIP2 ADP-ribosylation factor interacting protein 2
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
AXL AXL receptor tyrosine kinase
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIN1 bridging integrator 1
C21ORF33 chromosome 21 open reading frame 33
C2CD5 C2 calcium-dependent domain containing 5
CAV2 caveolin 2
CBR3 carbonyl reductase 3
CCDC22 coiled-coil domain containing 22
CDC25B cell division cycle 25B
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CHMP4A charged multivesicular body protein 4A
CLGN calmegin
COX11 COX11 cytochrome c oxidase copper chaperone
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
EIF5 eukaryotic translation initiation factor 5
ERGIC2 ERGIC and golgi 2
ETFB electron-transfer-flavoprotein, beta polypeptide
FAM216A family with sequence similarity 216, member A
FASTKD3 FAST kinase domains 3
FKBP3 FK506 binding protein 3, 25kDa
FPGS folylpolyglutamate synthase
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GGT1 gamma-glutamyltransferase 1
GMDS GDP-mannose 4,6-dehydratase
GRSF1 G-rich RNA sequence binding factor 1
HDDC2 HD domain containing 2
HEATR1 HEAT repeat containing 1
HN1 hematological and neurological expressed 1
IFRD2 interferon-related developmental regulator 2
IGFBP6 insulin-like growth factor binding protein 6
IL13RA2 interleukin 13 receptor, alpha 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIF2C kinesin family member 2C
LAMB3 laminin, beta 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRP10 low density lipoprotein receptor-related protein 10
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MRPL12 mitochondrial ribosomal protein L12
MRPL20 mitochondrial ribosomal protein L20
MRPS16 mitochondrial ribosomal protein S16
MRPS35 mitochondrial ribosomal protein S35
MRPS7 mitochondrial ribosomal protein S7
MYBPC1 myosin binding protein C, slow type
NBEA neurobeachin
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NFIB nuclear factor I/B
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NUP210 nucleoporin 210kDa
NUP62 nucleoporin 62kDa
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PFAS phosphoribosylformylglycinamidine synthase
PIP prolactin-induced protein
PLA2G16 phospholipase A2, group XVI
PLCB4 phospholipase C, beta 4
PLS1 plastin 1
PLSCR3 phospholipid scramblase 3
PNKP polynucleotide kinase 3'-phosphatase
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPARG peroxisome proliferator-activated receptor gamma
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRMT1 protein arginine methyltransferase 1
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGES prostaglandin E synthase
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
RRM1 ribonucleotide reductase M1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SPATA20 spermatogenesis associated 20
SRPX sushi-repeat containing protein, X-linked
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGM2 transglutaminase 2
TMEM135 transmembrane protein 135
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOM1L1 target of myb1 (chicken)-like 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM16 tripartite motif containing 16
TRIP6 thyroid hormone receptor interactor 6
TSPAN13 tetraspanin 13
TYMS thymidylate synthetase
UBE3C ubiquitin protein ligase E3C
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
Funding