BRD-K84595254_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K84595254_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AKAP8L A kinase (PRKA) anchor protein 8-like
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
AREG amphiregulin
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C6ORF48 chromosome 6 open reading frame 48
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ELF1 E74-like factor 1 (ets domain transcription factor)
FAM60A family with sequence similarity 60, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
IER2 immediate early response 2
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MKRN1 makorin ring finger protein 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
OXSR1 oxidative stress responsive 1
PDLIM5 PDZ and LIM domain 5
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
RLF rearranged L-myc fusion
S100A10 S100 calcium binding protein A10
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SRRM2 serine/arginine repetitive matrix 2
STC2 stanniocalcin 2
STOM stomatin
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCL1A T-cell leukemia/lymphoma 1A
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D2 TSC22 domain family, member 2
TXNL4B thioredoxin-like 4B
UGCG UDP-glucose ceramide glucosyltransferase
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZEB2 zinc finger E-box binding homeobox 2
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF430 zinc finger protein 430
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
ATMIN ATM interactor
C1QB complement component 1, q subcomponent, B chain
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CADPS2 Ca++-dependent secretion activator 2
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD14 CD14 molecule
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLU clusterin
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
EGLN3 egl-9 family hypoxia-inducible factor 3
FAM13A family with sequence similarity 13, member A
FAM178A family with sequence similarity 178, member A
FASTKD1 FAST kinase domains 1
FBXW2 F-box and WD repeat domain containing 2
FCGBP Fc fragment of IgG binding protein
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INTS3 integrator complex subunit 3
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
LEPROTL1 leptin receptor overlapping transcript-like 1
LIMCH1 LIM and calponin homology domains 1
MAP7 microtubule-associated protein 7
MDH1 malate dehydrogenase 1, NAD (soluble)
METTL13 methyltransferase like 13
MKKS McKusick-Kaufman syndrome
MREG melanoregulin
MSRB1 methionine sulfoxide reductase B1
MUC4 mucin 4, cell surface associated
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NMT1 N-myristoyltransferase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
PCSK1 proprotein convertase subtilisin/kexin type 1
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PRUNE2 prune homolog 2 (Drosophila)
PSRC1 proline/serine-rich coiled-coil 1
RAB13 RAB13, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SNX10 sorting nexin 10
TBC1D31 TBC1 domain family, member 31
TSEN2 TSEN2 tRNA splicing endonuclease subunit
USP34 ubiquitin specific peptidase 34
WNT5A wingless-type MMTV integration site family, member 5A