BRD-K84595254_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K84595254_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AKAP8L A kinase (PRKA) anchor protein 8-like
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
BRD4 bromodomain containing 4
CHIC2 cysteine-rich hydrophobic domain 2
CHN2 chimerin 2
CHSY1 chondroitin sulfate synthase 1
CPM carboxypeptidase M
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESR1 estrogen receptor 1
FGG fibrinogen gamma chain
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FST follistatin
FYB FYN binding protein
GABPB1 GA binding protein transcription factor, beta subunit 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
IER2 immediate early response 2
IER3 immediate early response 3
IQGAP1 IQ motif containing GTPase activating protein 1
JUN jun proto-oncogene
KLF9 Kruppel-like factor 9
NTS neurotensin
PHACTR2 phosphatase and actin regulator 2
PRRC2C proline-rich coiled-coil 2C
PTPRC protein tyrosine phosphatase, receptor type, C
RBP1 retinol binding protein 1, cellular
SCAF11 SR-related CTD-associated factor 11
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STOM stomatin
TF transferrin
TGIF1 TGFB-induced factor homeobox 1
THBD thrombomodulin
THBS1 thrombospondin 1
TNNT1 troponin T type 1 (skeletal, slow)
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
VCAN versican
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CD44 CD44 molecule (Indian blood group)
CLIC4 chloride intracellular channel 4
CSRP1 cysteine and glycine-rich protein 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EIF5 eukaryotic translation initiation factor 5
FAM57A family with sequence similarity 57, member A
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IFI27 interferon, alpha-inducible protein 27
MEIS1 Meis homeobox 1
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PRPF4 pre-mRNA processing factor 4
PRUNE2 prune homolog 2 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFTPA2 surfactant protein A2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYBU syntabulin (syntaxin-interacting)
ZW10 zw10 kinetochore protein
Funding