BRD-K84595254_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

249 genes differentially expressed following the BRD-K84595254_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
AEBP1 AE binding protein 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AKIRIN1 akirin 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA3 annexin A3
AREG amphiregulin
ASCL1 achaete-scute family bHLH transcription factor 1
ASPN asporin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG2 BCL2-associated athanogene 2
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
CCNL1 cyclin L1
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFD complement factor D (adipsin)
CGA glycoprotein hormones, alpha polypeptide
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC5A C-type lectin domain family 5, member A
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CST6 cystatin E/M
CTGF connective tissue growth factor
CTSB cathepsin B
CTSV cathepsin V
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA4 EPH receptor A4
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FAM60A family with sequence similarity 60, member A
FASN fatty acid synthase
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXC1 forkhead box C1
FOXO1 forkhead box O1
FST follistatin
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GSTP1 glutathione S-transferase pi 1
HCAR3 hydroxycarboxylic acid receptor 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HES1 hes family bHLH transcription factor 1
HIC2 hypermethylated in cancer 2
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK5 kallikrein-related peptidase 5
KRT6B keratin 6B, type II
LAMP3 lysosomal-associated membrane protein 3
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MMP19 matrix metallopeptidase 19
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
OASL 2'-5'-oligoadenylate synthetase-like
PDE8B phosphodiesterase 8B
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTPRO protein tyrosine phosphatase, receptor type, O
PUM1 pumilio RNA-binding family member 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RLF rearranged L-myc fusion
RRAGC Ras-related GTP binding C
S100A12 S100 calcium binding protein A12
SASH1 SAM and SH3 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC62 SEC62 homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SOSTDC1 sclerostin domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STK17B serine/threonine kinase 17b
STOM stomatin
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPM4 tropomyosin 4
TXNL4B thioredoxin-like 4B
UBQLN2 ubiquilin 2
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF430 zinc finger protein 430

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AIM1 absent in melanoma 1
ALAS1 5'-aminolevulinate synthase 1
AMIGO2 adhesion molecule with Ig-like domain 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ATM ATM serine/threonine kinase
ATMIN ATM interactor
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
C3ORF14 chromosome 3 open reading frame 14
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
COG2 component of oligomeric golgi complex 2
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CSK c-src tyrosine kinase
CX3CR1 chemokine (C-X3-C motif) receptor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL2 dihydropyrimidinase-like 2
EIF5 eukaryotic translation initiation factor 5
EXOSC4 exosome component 4
EXT1 exostosin glycosyltransferase 1
F12 coagulation factor XII (Hageman factor)
FANCF Fanconi anemia, complementation group F
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GIMAP6 GTPase, IMAP family member 6
GJA1 gap junction protein, alpha 1, 43kDa
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INTS3 integrator complex subunit 3
JCHAIN joining chain of multimeric IgA and IgM
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLHDC2 kelch domain containing 2
KRCC1 lysine-rich coiled-coil 1
LINC00341 long intergenic non-protein coding RNA 341
MAT2A methionine adenosyltransferase II, alpha
METTL13 methyltransferase like 13
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSLN mesothelin
NMRK1 nicotinamide riboside kinase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NREP neuronal regeneration related protein
NT5DC2 5'-nucleotidase domain containing 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDGFA platelet-derived growth factor alpha polypeptide
PDZD2 PDZ domain containing 2
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PNN pinin, desmosome associated protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRUNE2 prune homolog 2 (Drosophila)
PTPRE protein tyrosine phosphatase, receptor type, E
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNF167 ring finger protein 167
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SRSF7 serine/arginine-rich splicing factor 7
STEAP3 STEAP family member 3, metalloreductase
TBC1D16 TBC1 domain family, member 16
TBC1D31 TBC1 domain family, member 31
TDO2 tryptophan 2,3-dioxygenase
TFPI2 tissue factor pathway inhibitor 2
THYN1 thymocyte nuclear protein 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN12 tetraspanin 12
VCAM1 vascular cell adhesion molecule 1
XBP1 X-box binding protein 1
ZNF302 zinc finger protein 302
ZNF32 zinc finger protein 32
ZNF623 zinc finger protein 623
ZW10 zw10 kinetochore protein
Funding