BRD-K84937637_A-275_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

225 genes differentially expressed following the BRD-K84937637_A-275_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACAA1 acetyl-CoA acyltransferase 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ANGPT1 angiopoietin 1
ANKRD28 ankyrin repeat domain 28
AQP1 aquaporin 1 (Colton blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL8B ADP-ribosylation factor-like 8B
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CCNL1 cyclin L1
CCR7 chemokine (C-C motif) receptor 7
CD1E CD1e molecule
CDK7 cyclin-dependent kinase 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHKA choline kinase alpha
CLK4 CDC-like kinase 4
COL5A1 collagen, type V, alpha 1
CYLD cylindromatosis (turban tumor syndrome)
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFNA1 ephrin-A1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM117A family with sequence similarity 117, member A
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
IRF1 interferon regulatory factor 1
ISG15 ISG15 ubiquitin-like modifier
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0922 KIAA0922
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LGALS4 lectin, galactoside-binding, soluble, 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAM1 neural cell adhesion molecule 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
ORM1 orosomucoid 1
PDLIM5 PDZ and LIM domain 5
PHF3 PHD finger protein 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTBP2 polypyrimidine tract binding protein 2
RAB29 RAB29, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RFTN1 raftlin, lipid raft linker 1
RIOK3 RIO kinase 3
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSF1 remodeling and spacing factor 1
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SH2D1A SH2 domain containing 1A
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARP TCR gamma alternate reading frame protein
TEX10 testis expressed 10
TKTL1 transketolase-like 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
UBE2H ubiquitin-conjugating enzyme E2H
WEE1 WEE1 G2 checkpoint kinase
WLS wntless Wnt ligand secretion mediator
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACLY ATP citrate lyase
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
AQP3 aquaporin 3 (Gill blood group)
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
B3GNT1
CA12 carbonic anhydrase XII
CAV2 caveolin 2
CBR1 carbonyl reductase 1
CCND1 cyclin D1
CD14 CD14 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKAP4 cytoskeleton-associated protein 4
COMT catechol-O-methyltransferase
COPS7A COP9 signalosome subunit 7A
CRABP2 cellular retinoic acid binding protein 2
CSK c-src tyrosine kinase
CST3 cystatin C
CSTA cystatin A (stefin A)
CTBP1 C-terminal binding protein 1
DCPS decapping enzyme, scavenger
DEFB1 defensin, beta 1
DUSP4 dual specificity phosphatase 4
DUT deoxyuridine triphosphatase
ECI2 enoyl-CoA delta isomerase 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERLIN2 ER lipid raft associated 2
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FERMT1 fermitin family member 1
FGFBP1 fibroblast growth factor binding protein 1
FKBP9 FK506 binding protein 9, 63 kDa
G0S2 G0/G1 switch 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPI glucose-6-phosphate isomerase
GSTP1 glutathione S-transferase pi 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HOXB2 homeobox B2
HOXB7 homeobox B7
HSPA2 heat shock 70kDa protein 2
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
KCTD12 potassium channel tetramerization domain containing 12
KEAP1 kelch-like ECH-associated protein 1
KLK11 kallikrein-related peptidase 11
KLK8 kallikrein-related peptidase 8
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL1 lysyl oxidase-like 1
LSM1 LSM1, U6 small nuclear RNA associated
LY6D lymphocyte antigen 6 complex, locus D
MAPK13 mitogen-activated protein kinase 13
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLEC malectin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC16 mucin 16, cell surface associated
NBN nibrin
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NID1 nidogen 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMU neuromedin U
NQO1 NAD(P)H dehydrogenase, quinone 1
OAT ornithine aminotransferase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCCB propionyl CoA carboxylase, beta polypeptide
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDIA3 protein disulfide isomerase family A, member 3
PDIA6 protein disulfide isomerase family A, member 6
PGK1 phosphoglycerate kinase 1
PGLS 6-phosphogluconolactonase
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PRDX4 peroxiredoxin 4
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPP25 ribonuclease P/MRP 25kDa subunit
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SPAG7 sperm associated antigen 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SPRR1B small proline-rich protein 1B
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFDP1 transcription factor Dp-1
TMEM109 transmembrane protein 109
TMEM45A transmembrane protein 45A
TMEM5 transmembrane protein 5
TMEM97 transmembrane protein 97
TPM2 tropomyosin 2 (beta)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase