BRD-K85275009_methyl 4-hydroxy-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate MAY_9_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K85275009_methyl 4-hydroxy-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate MAY_9_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD9 CD9 molecule
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CP ceruloplasmin (ferroxidase)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXADR coxsackie virus and adenovirus receptor
DCN decorin
DENND1B DENN/MADD domain containing 1B
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EFNB3 ephrin-B3
EPAS1 endothelial PAS domain protein 1
EXT1 exostosin glycosyltransferase 1
FABP6 fatty acid binding protein 6, ileal
FAM69A family with sequence similarity 69, member A
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
HBB hemoglobin, beta
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA8 heat shock 70kDa protein 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
INA internexin neuronal intermediate filament protein, alpha
ITM2C integral membrane protein 2C
KRT13 keratin 13, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
L1CAM L1 cell adhesion molecule
LDOC1 leucine zipper, down-regulated in cancer 1
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MX1 MX dynamin-like GTPase 1
NRGN neurogranin (protein kinase C substrate, RC3)
NRP1 neuropilin 1
PDE8B phosphodiesterase 8B
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTPRO protein tyrosine phosphatase, receptor type, O
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RTN1 reticulon 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOCS2 suppressor of cytokine signaling 2
SRGN serglycin
TBX2 T-box 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TRIB2 tribbles pseudokinase 2
TUBA1A tubulin, alpha 1a
TUBB6 tubulin, beta 6 class V
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR7 WD repeat domain 7
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANK2 ankyrin 2, neuronal
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CDC42 cell division cycle 42
CELF2 CUGBP, Elav-like family member 2
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CLDN18 claudin 18
CLNS1A chloride channel, nucleotide-sensitive, 1A
CTSG cathepsin G
CTTN cortactin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAR2 fatty acyl CoA reductase 2
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
GAMT guanidinoacetate N-methyltransferase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
HIST1H2BD histone cluster 1, H2bd
KRT10 keratin 10, type I
MFSD10 major facilitator superfamily domain containing 10
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDZK1 PDZ domain containing 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
RAB4A RAB4A, member RAS oncogene family
RNF167 ring finger protein 167
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS5 ribosomal protein S5
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SORD sorbitol dehydrogenase
TFF3 trefoil factor 3 (intestinal)
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
USP6NL USP6 N-terminal like
ZIC1 Zic family member 1
Funding