BRD-K85402309_dovitinib_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K85402309_dovitinib_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CALML5 calmodulin-like 5
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CXCR4 chemokine (C-X-C motif) receptor 4
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FOXO1 forkhead box O1
GARS glycyl-tRNA synthetase
GAS6 growth arrest-specific 6
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HOXD1 homeobox D1
IFITM1 interferon induced transmembrane protein 1
IL1R2 interleukin 1 receptor, type II
KLK10 kallikrein-related peptidase 10
KLK5 kallikrein-related peptidase 5
KLK7 kallikrein-related peptidase 7
KLK8 kallikrein-related peptidase 8
LCN2 lipocalin 2
LPIN1 lipin 1
MDK midkine (neurite growth-promoting factor 2)
MEIS1 Meis homeobox 1
MUC16 mucin 16, cell surface associated
NDN necdin, melanoma antigen (MAGE) family member
NEB nebulin
NMU neuromedin U
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NXN nucleoredoxin
PAEP progestagen-associated endometrial protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRAF2 PRA1 domain family, member 2
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PXDN peroxidasin
PYCARD PYD and CARD domain containing
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A14 S100 calcium binding protein A14
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SPON1 spondin 1, extracellular matrix protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNNT1 troponin T type 1 (skeletal, slow)
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TSPAN4 tetraspanin 4
WT1 Wilms tumor 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADM adrenomedullin
BMP2 bone morphogenetic protein 2
CA12 carbonic anhydrase XII
CDC20 cell division cycle 20
CDKN2A cyclin-dependent kinase inhibitor 2A
CSRP2 cysteine and glycine-rich protein 2
CTSZ cathepsin Z
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSG2 desmoglein 2
FNDC3B fibronectin type III domain containing 3B
GLDC glycine dehydrogenase (decarboxylating)
GLIPR1 GLI pathogenesis-related 1
HBB hemoglobin, beta
MAOA monoamine oxidase A
MSX1 msh homeobox 1
NDRG1 N-myc downstream regulated 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
RNH1 ribonuclease/angiogenin inhibitor 1
SALL1 spalt-like transcription factor 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPEN spen family transcriptional repressor
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRRM2 serine/arginine repetitive matrix 2
TICAM1 toll-like receptor adaptor molecule 1
VCAN versican
VLDLR very low density lipoprotein receptor
WIF1 WNT inhibitory factor 1
Funding