BRD-K85606544_HKI-272_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

401 genes differentially expressed following the BRD-K85606544_HKI-272_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
C14ORF132 chromosome 14 open reading frame 132
C1ORF56 chromosome 1 open reading frame 56
CA2 carbonic anhydrase II
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAPG capping protein (actin filament), gelsolin-like
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL10 chemokine (C-X-C motif) ligand 10
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFS embryonal Fyn-associated substrate
ELF4 E74-like factor 4 (ets domain transcription factor)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM69A family with sequence similarity 69, member A
FBXL12 F-box and leucine-rich repeat protein 12
FGFR2 fibroblast growth factor receptor 2
FOLR1 folate receptor 1 (adult)
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD5 frizzled class receptor 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GGT1 gamma-glutamyltransferase 1
GMPR guanosine monophosphate reductase
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRB7 growth factor receptor-bound protein 7
GTPBP2 GTP binding protein 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBP1 HMG-box transcription factor 1
HDAC9 histone deacetylase 9
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HOXD1 homeobox D1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL10RA interleukin 10 receptor, alpha
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
KLHDC10 kelch domain containing 10
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
LDB3 LIM domain binding 3
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100505650 uncharacterized LOC100505650
LRP12 low density lipoprotein receptor-related protein 12
LY96 lymphocyte antigen 96
MAST4 microtubule associated serine/threonine kinase family member 4
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MOSPD1 motile sperm domain containing 1
MSMO1 methylsterol monooxygenase 1
MT1M metallothionein 1M
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NCOA3 nuclear receptor coactivator 3
NEU1 sialidase 1 (lysosomal sialidase)
NLRP2 NLR family, pyrin domain containing 2
NMRK1 nicotinamide riboside kinase 1
NUPR1 nuclear protein, transcriptional regulator, 1
NVL nuclear VCP-like
OPTN optineurin
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PEA15 phosphoprotein enriched in astrocytes 15
PEG3 paternally expressed 3
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RAB29 RAB29, member RAS oncogene family
RAB32 RAB32, member RAS oncogene family
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RBM8A RNA binding motif protein 8A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNMT RNA (guanine-7-) methyltransferase
RRAGC Ras-related GTP binding C
RSAD2 radical S-adenosyl methionine domain containing 2
RTN2 reticulon 2
SCG5 secretogranin V
SDCBP syndecan binding protein (syntenin)
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMIM7 small integral membrane protein 7
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SST somatostatin
STX3 syntaxin 3
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TDP2 tyrosyl-DNA phosphodiesterase 2
TESK1 testis-specific kinase 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UBE2G1 ubiquitin-conjugating enzyme E2G 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFYVE26 zinc finger, FYVE domain containing 26
ZMYM2 zinc finger, MYM-type 2
ZNF292 zinc finger protein 292
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ABHD2 abhydrolase domain containing 2
ACAT1 acetyl-CoA acetyltransferase 1
ACP6 acid phosphatase 6, lysophosphatidic
ADI1 acireductone dioxygenase 1
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
ANXA6 annexin A6
APMAP adipocyte plasma membrane associated protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL3 ADP-ribosylation factor-like 3
ASPH aspartate beta-hydroxylase
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
B3GNT1
BCHE butyrylcholinesterase
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
C3 complement component 3
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CD302 CD302 molecule
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC123 cell division cycle 123
CDH19 cadherin 19, type 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CFI complement factor I
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COASY CoA synthase
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL9A3 collagen, type IX, alpha 3
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
COX11 COX11 cytochrome c oxidase copper chaperone
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST7 cystatin F (leukocystatin)
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCPS decapping enzyme, scavenger
DCXR dicarbonyl/L-xylulose reductase
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
ELAVL1 ELAV like RNA binding protein 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM120A family with sequence similarity 120A
FBN1 fibrillin 1
FERMT1 fermitin family member 1
FLNB filamin B, beta
FPGS folylpolyglutamate synthase
FSTL1 follistatin-like 1
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
G0S2 G0/G1 switch 2
GLRX5 glutaredoxin 5
GLT8D1 glycosyltransferase 8 domain containing 1
GPI glucose-6-phosphate isomerase
GPX1 glutathione peroxidase 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLTF helicase-like transcription factor
HOXB7 homeobox B7
HOXC6 homeobox C6
ICMT isoprenylcysteine carboxyl methyltransferase
IER3 immediate early response 3
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO4 importin 4
IPO5 importin 5
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KANK2 KN motif and ankyrin repeat domains 2
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDM1A lysine (K)-specific demethylase 1A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
KRT18 keratin 18, type I
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MBNL1 muscleblind-like splicing regulator 1
MGP matrix Gla protein
MIA melanoma inhibitory activity
MKI67 marker of proliferation Ki-67
MOK MOK protein kinase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPTX2 neuronal pentraxin II
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDHB pyruvate dehydrogenase (lipoamide) beta
PEBP1 phosphatidylethanolamine binding protein 1
PFAS phosphoribosylformylglycinamidine synthase
PGD phosphogluconate dehydrogenase
PGM1 phosphoglucomutase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PNKP polynucleotide kinase 3'-phosphatase
PPARG peroxisome proliferator-activated receptor gamma
PRDX3 peroxiredoxin 3
PRDX4 peroxiredoxin 4
PRMT1 protein arginine methyltransferase 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRSS23 protease, serine, 23
PTMA prothymosin, alpha
PYGL phosphorylase, glycogen, liver
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBPMS RNA binding protein with multiple splicing
RCAN1 regulator of calcineurin 1
RER1 retention in endoplasmic reticulum sorting receptor 1
RHOBTB3 Rho-related BTB domain containing 3
RPN2 ribophorin II
RPS11 ribosomal protein S11
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RUVBL2 RuvB-like AAA ATPase 2
S100A2 S100 calcium binding protein A2
S100B S100 calcium binding protein B
SACS sacsin molecular chaperone
SDC2 syndecan 2
SEPHS1 selenophosphate synthetase 1
SEPT11 septin 11
SERBP1 SERPINE1 mRNA binding protein 1
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLIRP SRA stem-loop interacting RNA binding protein
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TMX1 thioredoxin-related transmembrane protein 1
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VCAN versican
VRK1 vaccinia related kinase 1
WWTR1 WW domain containing transcription regulator 1
ZCCHC24 zinc finger, CCHC domain containing 24