BRD-K85606544_HKI-272_HEC108_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K85606544_HKI-272_HEC108_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX15B arachidonate 15-lipoxygenase, type B
AQP1 aquaporin 1 (Colton blood group)
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
C3ORF14 chromosome 3 open reading frame 14
CCND2 cyclin D2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC4 chloride intracellular channel 4
CTH cystathionine gamma-lyase
CTSS cathepsin S
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DHCR24 24-dehydrocholesterol reductase
DPYD dihydropyrimidine dehydrogenase
EFS embryonal Fyn-associated substrate
FAM129A family with sequence similarity 129, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
KLHL21 kelch-like family member 21
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LMO4 LIM domain only 4
LSP1 lymphocyte-specific protein 1
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NEFH neurofilament, heavy polypeptide
NEFM neurofilament, medium polypeptide
NUAK1 NUAK family, SNF1-like kinase, 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORC1 origin recognition complex, subunit 1
OSBPL1A oxysterol binding protein-like 1A
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PDLIM1 PDZ and LIM domain 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLTP phospholipid transfer protein
PROM1 prominin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
REEP1 receptor accessory protein 1
RNF167 ring finger protein 167
RTN2 reticulon 2
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNX11 sorting nexin 11
SPAG16 sperm associated antigen 16
SQLE squalene epoxidase
TUBA4A tubulin, alpha 4a
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHSG alpha-2-HS-glycoprotein
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMDHD2 amidohydrolase domain containing 2
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CDK6 cyclin-dependent kinase 6
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
IER3 immediate early response 3
IGKC immunoglobulin kappa constant
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTF lactotransferrin
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAL mal, T-cell differentiation protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
POSTN periostin, osteoblast specific factor
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RPIA ribose 5-phosphate isomerase A
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOX4 SRY (sex determining region Y)-box 4
TCL1A T-cell leukemia/lymphoma 1A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TMPRSS2 transmembrane protease, serine 2
TRAF4 TNF receptor-associated factor 4
TRBC1 T cell receptor beta constant 1
UXS1 UDP-glucuronate decarboxylase 1
VGLL4 vestigial-like family member 4