BRD-K85606544_HKI-272_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

45 genes differentially expressed following the BRD-K85606544_HKI-272_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
C14ORF1 chromosome 14 open reading frame 1
CAV2 caveolin 2
CFD complement factor D (adipsin)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDPS farnesyl diphosphate synthase
FTH1 ferritin, heavy polypeptide 1
GLUL glutamate-ammonia ligase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MSMO1 methylsterol monooxygenase 1
NPC1 Niemann-Pick disease, type C1
NSDHL NAD(P) dependent steroid dehydrogenase-like
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VNN1 vanin 1

decreased expression

Symbol Name
DKK1 dickkopf WNT signaling pathway inhibitor 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGA2 high mobility group AT-hook 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
MAGED1 melanoma antigen family D1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A2 nuclear receptor subfamily 4, group A, member 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit