BRD-K85606544_HKI-272_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K85606544_HKI-272_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
ALDOC aldolase C, fructose-bisphosphate
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
GAA glucosidase, alpha; acid
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
JAG1 jagged 1
MMP7 matrix metallopeptidase 7
MVP major vault protein
NOTCH2NL notch 2 N-terminal like
NT5E 5'-nucleotidase, ecto (CD73)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TACSTD2 tumor-associated calcium signal transducer 2
TSC22D1 TSC22 domain family, member 1
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ATAD2 ATPase family, AAA domain containing 2
CCNA2 cyclin A2
CD200 CD200 molecule
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CENPU centromere protein U
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ERGIC2 ERGIC and golgi 2
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLT1B golgi transport 1B
HIST1H4C histone cluster 1, H4c
IGLL1 immunoglobulin lambda-like polypeptide 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MEA1 male-enhanced antigen 1
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
OAT ornithine aminotransferase
PCNA proliferating cell nuclear antigen
PTTG1 pituitary tumor-transforming 1
RECQL RecQ helicase-like
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
THBS2 thrombospondin 2
TYMS thymidylate synthetase