BRD-K85606544_HKI-272_MDST8_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K85606544_HKI-272_MDST8_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BIN1 bridging integrator 1
C1QA complement component 1, q subcomponent, A chain
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CD24 CD24 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP1B charged multivesicular body protein 1B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
CXCL12 chemokine (C-X-C motif) ligand 12
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EIF5A eukaryotic translation initiation factor 5A
EMX2 empty spiracles homeobox 2
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
KDM5A lysine (K)-specific demethylase 5A
KLF2 Kruppel-like factor 2
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLK2 polo-like kinase 2
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SQLE squalene epoxidase
STC2 stanniocalcin 2
TBL1X transducin (beta)-like 1X-linked
TNNT1 troponin T type 1 (skeletal, slow)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
USP33 ubiquitin specific peptidase 33
VCAM1 vascular cell adhesion molecule 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD200 CD200 molecule
CES1 carboxylesterase 1
CFI complement factor I
COL4A5 collagen, type IV, alpha 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R2 cytochrome b5 reductase 2
DLK1 delta-like 1 homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EMP3 epithelial membrane protein 3
ETV1 ets variant 1
EXOSC4 exosome component 4
FABP1 fatty acid binding protein 1, liver
FAM46A family with sequence similarity 46, member A
FAP fibroblast activation protein, alpha
FEN1 flap structure-specific endonuclease 1
FNDC3B fibronectin type III domain containing 3B
GLIPR1 GLI pathogenesis-related 1
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
IFI16 interferon, gamma-inducible protein 16
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
LAMP3 lysosomal-associated membrane protein 3
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LPXN leupaxin
LTF lactotransferrin
MALT1 MALT1 paracaspase
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PID1 phosphotyrosine interaction domain containing 1
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PNMAL1 paraneoplastic Ma antigen family-like 1
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PSD3 pleckstrin and Sec7 domain containing 3
RHOBTB3 Rho-related BTB domain containing 3
RIN2 Ras and Rab interactor 2
RNH1 ribonuclease/angiogenin inhibitor 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
TMEM100 transmembrane protein 100
TMEM87A transmembrane protein 87A
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VCAN versican
VSNL1 visinin-like 1
ZMIZ1 zinc finger, MIZ-type containing 1