BRD-K85606544_HKI-272_NCIH2073_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

122 genes differentially expressed following the BRD-K85606544_HKI-272_NCIH2073_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG1 adhesion G protein-coupled receptor G1
ALDOC aldolase C, fructose-bisphosphate
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CD99 CD99 molecule
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
CLU clusterin
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EBP emopamil binding protein (sterol isomerase)
EFNB2 ephrin-B2
FASN fatty acid synthase
GARS glycyl-tRNA synthetase
GLUL glutamate-ammonia ligase
GRB10 growth factor receptor-bound protein 10
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPG2 heparan sulfate proteoglycan 2
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCAM melanoma cell adhesion molecule
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICALL1 MICAL-like 1
MSMO1 methylsterol monooxygenase 1
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NR2F2 nuclear receptor subfamily 2, group F, member 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFC platelet derived growth factor C
PDZD2 PDZ domain containing 2
PHGDH phosphoglycerate dehydrogenase
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
RGCC regulator of cell cycle
RHOB ras homolog family member B
RNF19B ring finger protein 19B
S100A10 S100 calcium binding protein A10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCYL3 SCY1-like 3 (S. cerevisiae)
SDCBP syndecan binding protein (syntenin)
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
SYNGR3 synaptogyrin 3
TARS threonyl-tRNA synthetase
TLR2 toll-like receptor 2
TPPP3 tubulin polymerization-promoting protein family member 3
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
VAT1 vesicle amine transport 1
VWF von Willebrand factor
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
C6ORF62 chromosome 6 open reading frame 62
CA1 carbonic anhydrase I
CCND1 cyclin D1
CHGB chromogranin B
COL5A2 collagen, type V, alpha 2
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL13 chemokine (C-X-C motif) ligand 13
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP2 dual specificity phosphatase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM46A family with sequence similarity 46, member A
FERMT1 fermitin family member 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GREM1 gremlin 1, DAN family BMP antagonist
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
INSM1 insulinoma-associated 1
JADE2 jade family PHD finger 2
LAMB1 laminin, beta 1
LUM lumican
MOK MOK protein kinase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCSK1 proprotein convertase subtilisin/kexin type 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
TFPI2 tissue factor pathway inhibitor 2
TOR1A torsin family 1, member A (torsin A)
UGDH UDP-glucose 6-dehydrogenase
WWTR1 WW domain containing transcription regulator 1