BRD-K85606544_HKI-272_NOMO1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K85606544_HKI-272_NOMO1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABLIM1 actin binding LIM protein 1
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ALB albumin
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BLNK B-cell linker
C3ORF14 chromosome 3 open reading frame 14
CARS cysteinyl-tRNA synthetase
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
CLIC4 chloride intracellular channel 4
COL16A1 collagen, type XVI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
EBP emopamil binding protein (sterol isomerase)
ELOVL5 ELOVL fatty acid elongase 5
EPAS1 endothelial PAS domain protein 1
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FADS3 fatty acid desaturase 3
FAM129A family with sequence similarity 129, member A
FGG fibrinogen gamma chain
FHOD3 formin homology 2 domain containing 3
FN1 fibronectin 1
GAGE3 G antigen 3
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GRB7 growth factor receptor-bound protein 7
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPG2 heparan sulfate proteoglycan 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIAA0226L KIAA0226-like
LDLR low density lipoprotein receptor
LMOD1 leiomodin 1 (smooth muscle)
LPAR6 lysophosphatidic acid receptor 6
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MYO1B myosin IB
NARFL nuclear prelamin A recognition factor-like
NIT1 nitrilase 1
NNMT nicotinamide N-methyltransferase
NOX4 NADPH oxidase 4
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A10 S100 calcium binding protein A10
SARS seryl-tRNA synthetase
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC5 serine incorporator 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC1A structural maintenance of chromosomes 1A
SQLE squalene epoxidase
SULF1 sulfatase 1
TARS threonyl-tRNA synthetase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNS1 tensin 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
AMPD3 adenosine monophosphate deaminase 3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARPC5L actin related protein 2/3 complex, subunit 5-like
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL8 chemokine (C-C motif) ligand 8
CCP110 centriolar coiled coil protein 110kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
CP ceruloplasmin (ferroxidase)
CTSG cathepsin G
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DKC1 dyskeratosis congenita 1, dyskerin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4E eukaryotic translation initiation factor 4E
FABP7 fatty acid binding protein 7, brain
FAM46A family with sequence similarity 46, member A
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GSTM3 glutathione S-transferase mu 3 (brain)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDM5D lysine (K)-specific demethylase 5D
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LTF lactotransferrin
LY75 lymphocyte antigen 75
MAP7 microtubule-associated protein 7
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MGLL monoglyceride lipase
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MRPL12 mitochondrial ribosomal protein L12
MRPL3 mitochondrial ribosomal protein L3
MRPS2 mitochondrial ribosomal protein S2
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYCBP MYC binding protein
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOLC1 nucleolar and coiled-body phosphoprotein 1
PLAUR plasminogen activator, urokinase receptor
PLEK pleckstrin
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RELN reelin
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPP1 secreted phosphoprotein 1
SQRDL sulfide quinone reductase-like (yeast)
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TXNIP thioredoxin interacting protein
ZIC1 Zic family member 1