BRD-K85606544_HKI-272_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K85606544_HKI-272_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX4 brain expressed, X-linked 4
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCDC92 coiled-coil domain containing 92
CPT1A carnitine palmitoyltransferase 1A (liver)
CRABP1 cellular retinoic acid binding protein 1
CRYAB crystallin, alpha B
DDIT4 DNA-damage-inducible transcript 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
GARS glycyl-tRNA synthetase
GSTA1 glutathione S-transferase alpha 1
H3F3B H3 histone, family 3B (H3.3B)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
INHBE inhibin, beta E
KLF6 Kruppel-like factor 6
MAGED2 melanoma antigen family D2
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STC2 stanniocalcin 2
STMN2 stathmin 2
SYT1 synaptotagmin I
TPD52 tumor protein D52
TUBA1A tubulin, alpha 1a
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPOT exportin, tRNA

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ANO1 anoctamin 1, calcium activated chloride channel
CCDC86 coiled-coil domain containing 86
GPI glucose-6-phosphate isomerase
IL1B interleukin 1, beta
KCTD12 potassium channel tetramerization domain containing 12
KRT7 keratin 7, type II
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
NOP56 NOP56 ribonucleoprotein
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
PPIF peptidylprolyl isomerase F
SRM spermidine synthase
TGM2 transglutaminase 2
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10