BRD-K85606544_HKI-272_SKMEL28_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K85606544_HKI-272_SKMEL28_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CARTPT CART prepropeptide
CCND2 cyclin D2
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COL3A1 collagen, type III, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPYSL2 dihydropyrimidinase-like 2
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FBN1 fibrillin 1
FDPS farnesyl diphosphate synthase
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GARS glycyl-tRNA synthetase
GPER1 G protein-coupled estrogen receptor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
ISYNA1 inositol-3-phosphate synthase 1
JUND jun D proto-oncogene
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
LDLR low density lipoprotein receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PLSCR3 phospholipid scramblase 3
PRSS21 protease, serine, 21 (testisin)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBPMS RNA binding protein with multiple splicing
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STK26 serine/threonine protein kinase 26
SULF1 sulfatase 1
TFF3 trefoil factor 3 (intestinal)
TMEM97 transmembrane protein 97
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHIC2 cysteine-rich hydrophobic domain 2
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ERAP2 endoplasmic reticulum aminopeptidase 2
EXOSC4 exosome component 4
GOLGA3 golgin A3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA8 heat shock 70kDa protein 8
HTRA1 HtrA serine peptidase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGHM immunoglobulin heavy constant mu
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
KRT7 keratin 7, type II
MCOLN1 mucolipin 1
MTCL1 microtubule crosslinking factor 1
PFKP phosphofructokinase, platelet
PI3 peptidase inhibitor 3, skin-derived
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAA4 serum amyloid A4, constitutive
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC46A3 solute carrier family 46, member 3
SOX4 SRY (sex determining region Y)-box 4
SPRR3 small proline-rich protein 3
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TUBB2A tubulin, beta 2A class IIa
UPK1B uroplakin 1B
VAMP8 vesicle-associated membrane protein 8