BRD-K85606544_HKI-272_SW948_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K85606544_HKI-272_SW948_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AMPH amphiphysin
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CADM1 cell adhesion molecule 1
CCK cholecystokinin
CD9 CD9 molecule
CHRDL1 chordin-like 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOK5 docking protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
G0S2 G0/G1 switch 2
GPNMB glycoprotein (transmembrane) nmb
HSPA1A heat shock 70kDa protein 1A
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
MME membrane metallo-endopeptidase
NEFL neurofilament, light polypeptide
NUPR1 nuclear protein, transcriptional regulator, 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHGDH phosphoglycerate dehydrogenase
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SST somatostatin
TMEM100 transmembrane protein 100
TNNT1 troponin T type 1 (skeletal, slow)
TP53I3 tumor protein p53 inducible protein 3
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AKAP1 A kinase (PRKA) anchor protein 1
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
CD44 CD44 molecule (Indian blood group)
COL3A1 collagen, type III, alpha 1
DUSP6 dual specificity phosphatase 6
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FUCA1 fucosidase, alpha-L- 1, tissue
HMG20B high mobility group 20B
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUP210 nucleoporin 210kDa
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PPAP2C phosphatidic acid phosphatase type 2C
PRPF4 pre-mRNA processing factor 4
QDPR quinoid dihydropteridine reductase
RPL36 ribosomal protein L36
RRP1B ribosomal RNA processing 1B
SERINC5 serine incorporator 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC35F2 solute carrier family 35, member F2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1