BRD-K85606544_neratinib_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K85606544_neratinib_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ACTC1 actin, alpha, cardiac muscle 1
ANXA4 annexin A4
ASNS asparagine synthetase (glutamine-hydrolyzing)
CLIC4 chloride intracellular channel 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FAM134B family with sequence similarity 134, member B
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PRSS8 protease, serine, 8
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RHOB ras homolog family member B
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A14 S100 calcium binding protein A14
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SQLE squalene epoxidase
SYNGR2 synaptogyrin 2
TPD52 tumor protein D52
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
BIRC3 baculoviral IAP repeat containing 3
CCNE2 cyclin E2
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
COL1A1 collagen, type I, alpha 1
COL6A3 collagen, type VI, alpha 3
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYTL1 cytokine-like 1
GLIPR1 GLI pathogenesis-related 1
GPX7 glutathione peroxidase 7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUSAP1 nucleolar and spindle associated protein 1
PDLIM4 PDZ and LIM domain 4
RRM2 ribonucleotide reductase M2
SNAI2 snail family zinc finger 2
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
TMX4 thioredoxin-related transmembrane protein 4
TSPYL5 TSPY-like 5
Funding