BRD-K85853281_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K85853281_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AEBP1 AE binding protein 1
ALCAM activated leukocyte cell adhesion molecule
AQP1 aquaporin 1 (Colton blood group)
CLDN3 claudin 3
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
EGFL6 EGF-like-domain, multiple 6
ESR1 estrogen receptor 1
G0S2 G0/G1 switch 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LTBP1 latent transforming growth factor beta binding protein 1
MAOA monoamine oxidase A
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS21 protease, serine, 21 (testisin)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGS10 regulator of G-protein signaling 10
RRBP1 ribosome binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TNS1 tensin 1
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AMD1 adenosylmethionine decarboxylase 1
BAG5 BCL2-associated athanogene 5
BLCAP bladder cancer associated protein
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ETNK1 ethanolamine kinase 1
FAM46A family with sequence similarity 46, member A
FAM57A family with sequence similarity 57, member A
FASTKD5 FAST kinase domains 5
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOXA10 homeobox A10
HOXA5 homeobox A5
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PDLIM4 PDZ and LIM domain 4
PLK2 polo-like kinase 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTRH2 peptidyl-tRNA hydrolase 2
PTX3 pentraxin 3, long
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPL36 ribosomal protein L36
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TRIB2 tribbles pseudokinase 2
VGLL4 vestigial-like family member 4
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2