BRD-K85853281_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

288 genes differentially expressed following the BRD-K85853281_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALOX5 arachidonate 5-lipoxygenase
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
BSG basigin (Ok blood group)
C1ORF54 chromosome 1 open reading frame 54
C3ORF14 chromosome 3 open reading frame 14
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND2 cyclin D2
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CES2 carboxylesterase 2
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP5 charged multivesicular body protein 5
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL6A2 collagen, type VI, alpha 2
CTSS cathepsin S
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EID1 EP300 interacting inhibitor of differentiation 1
EIF5A eukaryotic translation initiation factor 5A
ESM1 endothelial cell-specific molecule 1
EVI2A ecotropic viral integration site 2A
EXPH5 exophilin 5
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
FRZB frizzled-related protein
FTH1 ferritin, heavy polypeptide 1
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GMFG glia maturation factor, gamma
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPSE heparanase
IDO1 indoleamine 2,3-dioxygenase 1
IL7R interleukin 7 receptor
INA internexin neuronal intermediate filament protein, alpha
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDR kinase insert domain receptor
KIAA1462 KIAA1462
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LDOC1 leucine zipper, down-regulated in cancer 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LTBP1 latent transforming growth factor beta binding protein 1
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MSR1 macrophage scavenger receptor 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDNF neuron-derived neurotrophic factor
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NEBL nebulette
NLRP2 NLR family, pyrin domain containing 2
NMRK1 nicotinamide riboside kinase 1
NMU neuromedin U
NRP1 neuropilin 1
NUAK1 NUAK family, SNF1-like kinase, 1
NUPR1 nuclear protein, transcriptional regulator, 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PFKM phosphofructokinase, muscle
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKCI protein kinase C, iota
PSENEN presenilin enhancer gamma secretase subunit
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RNASE6 ribonuclease, RNase A family, k6
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPINT1 serine peptidase inhibitor, Kunitz type 1
ST18 suppression of tumorigenicity 18, zinc finger
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TCF21 transcription factor 21
TCF4 transcription factor 4
TEK TEK tyrosine kinase, endothelial
THY1 Thy-1 cell surface antigen
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TPGS2 tubulin polyglutamylase complex subunit 2
TPSAB1 tryptase alpha/beta 1
TRHDE thyrotropin-releasing hormone degrading enzyme
TUBA1A tubulin, alpha 1a
VIM vimentin
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF423 zinc finger protein 423
ZNF532 zinc finger protein 532
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP12 A kinase (PRKA) anchor protein 12
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARG1 arginase 1
ASXL2 additional sex combs like transcriptional regulator 2
ATXN1 ataxin 1
AURKA aurora kinase A
BRPF1 bromodomain and PHD finger containing, 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP76 centrosomal protein 76kDa
CHD1 chromodomain helicase DNA binding protein 1
COL9A3 collagen, type IX, alpha 3
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EIF4A3 eukaryotic translation initiation factor 4A3
ELL2 elongation factor, RNA polymerase II, 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM208B family with sequence similarity 208, member B
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GDF15 growth differentiation factor 15
GGNBP2 gametogenetin binding protein 2
GOLGA8A golgin A8 family, member A
GRWD1 glutamate-rich WD repeat containing 1
GTPBP4 GTP binding protein 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOMER1 homer scaffolding protein 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IQGAP2 IQ motif containing GTPase activating protein 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KRT17 keratin 17, type I
LARP4B La ribonucleoprotein domain family, member 4B
LTF lactotransferrin
MAK16 MAK16 homolog (S. cerevisiae)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MBNL2 muscleblind-like splicing regulator 2
MCM10 minichromosome maintenance complex component 10
MED1 mediator complex subunit 1
MED13 mediator complex subunit 13
MRFAP1L1 Morf4 family associated protein 1-like 1
MSH6 mutS homolog 6
MTMR4 myotubularin related protein 4
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP56 NOP56 ribonucleoprotein
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
OXTR oxytocin receptor
PCM1 pericentriolar material 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PNN pinin, desmosome associated protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PROM1 prominin 1
RANBP2 RAN binding protein 2
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SETD2 SET domain containing 2
SETD5 SET domain containing 5
SIAH2 siah E3 ubiquitin protein ligase 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SNX11 sorting nexin 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SRSF7 serine/arginine-rich splicing factor 7
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TEX10 testis expressed 10
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAF4 TNF receptor-associated factor 4
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
USP1 ubiquitin specific peptidase 1
WAC WW domain containing adaptor with coiled-coil
WDR6 WD repeat domain 6
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF451 zinc finger protein 451
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