BRD-K85853281_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K85853281_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
CALD1 caldesmon 1
CAV2 caveolin 2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
CFH complement factor H
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CTSZ cathepsin Z
DDR2 discoidin domain receptor tyrosine kinase 2
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPYC epiphycan
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD5 FXYD domain containing ion transport regulator 5
GPM6A glycoprotein M6A
HAPLN1 hyaluronan and proteoglycan link protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IL1R1 interleukin 1 receptor, type I
KCNK3 potassium channel, two pore domain subfamily K, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LTA4H leukotriene A4 hydrolase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MUC16 mucin 16, cell surface associated
NEBL nebulette
NLGN4X neuroligin 4, X-linked
NLRP2 NLR family, pyrin domain containing 2
NSG1 neuron specific gene family member 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PCDH9 protocadherin 9
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PGK1 phosphoglycerate kinase 1
PLS3 plastin 3
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SH3BGR SH3 domain binding glutamate-rich protein
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM47 transmembrane protein 47
TPM2 tropomyosin 2 (beta)
UGP2 UDP-glucose pyrophosphorylase 2
VIM vimentin

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP3 aquaporin 3 (Gill blood group)
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BLCAP bladder cancer associated protein
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCL19 chemokine (C-C motif) ligand 19
CCL5 chemokine (C-C motif) ligand 5
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CGRRF1 cell growth regulator with ring finger domain 1
CHSY1 chondroitin sulfate synthase 1
COIL coilin
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
EIF5 eukaryotic translation initiation factor 5
FABP4 fatty acid binding protein 4, adipocyte
FAM208B family with sequence similarity 208, member B
FAM57A family with sequence similarity 57, member A
FEM1C fem-1 homolog c (C. elegans)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXJ3 forkhead box J3
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HILPDA hypoxia inducible lipid droplet-associated
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGL immunoglobulin lambda locus
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JCHAIN joining chain of multimeric IgA and IgM
KAT6B K(lysine) acetyltransferase 6B
KRT6B keratin 6B, type II
KYNU kynureninase
LMO2 LIM domain only 2 (rhombotin-like 1)
MAT2A methionine adenosyltransferase II, alpha
MED13 mediator complex subunit 13
MRPS30 mitochondrial ribosomal protein S30
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SESN1 sestrin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBP TATA box binding protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLK2 tousled-like kinase 2
TM2D3 TM2 domain containing 3
TOB1 transducer of ERBB2, 1
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VGLL4 vestigial-like family member 4
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZMYM2 zinc finger, MYM-type 2
ZNF267 zinc finger protein 267
ZW10 zw10 kinetochore protein
Funding