BRD-K86472598_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K86472598_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BGN biglycan
BTG2 BTG family, member 2
CALML5 calmodulin-like 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTGF connective tissue growth factor
CTSZ cathepsin Z
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
KRT81 keratin 81, type II
LRRC15 leucine rich repeat containing 15
MEIS2 Meis homeobox 2
MUC16 mucin 16, cell surface associated
MZB1 marginal zone B and B1 cell-specific protein
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDE8B phosphodiesterase 8B
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS1 regulator of G-protein signaling 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN7 tetraspanin 7
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ATXN1 ataxin 1
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CHSY1 chondroitin sulfate synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL6 chemokine (C-X-C motif) ligand 6
DCLK1 doublecortin-like kinase 1
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
FAM134B family with sequence similarity 134, member B
FKBP1A FK506 binding protein 1A, 12kDa
GDE1 glycerophosphodiester phosphodiesterase 1
HOXA10 homeobox A10
KIAA0101 KIAA0101
LBR lamin B receptor
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
MAPK6 mitogen-activated protein kinase 6
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NRIP1 nuclear receptor interacting protein 1
OSBPL8 oxysterol binding protein-like 8
OXSR1 oxidative stress responsive 1
PCNA proliferating cell nuclear antigen
PHF20 PHD finger protein 20
PRNP prion protein
RAB13 RAB13, member RAS oncogene family
RPS11 ribosomal protein S11
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SP3 Sp3 transcription factor
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
YME1L1 YME1-like 1 ATPase
Funding