BRD-K86472598_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K86472598_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANKRD10 ankyrin repeat domain 10
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARC activity-regulated cytoskeleton-associated protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CBR3 carbonyl reductase 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CTSL cathepsin L
CYB5R1 cytochrome b5 reductase 1
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DLX5 distal-less homeobox 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EGLN3 egl-9 family hypoxia-inducible factor 3
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL6R interleukin 6 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT16 keratin 16, type I
LEF1 lymphoid enhancer-binding factor 1
LOC100505650 uncharacterized LOC100505650
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MMP3 matrix metallopeptidase 3
MSX1 msh homeobox 1
NAMPT nicotinamide phosphoribosyltransferase
ODC1 ornithine decarboxylase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SERINC5 serine incorporator 5
SFN stratifin
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
TMEM45A transmembrane protein 45A
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APOD apolipoprotein D
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BMP4 bone morphogenetic protein 4
CTSC cathepsin C
DENND2D DENN/MADD domain containing 2D
ERBB2 erb-b2 receptor tyrosine kinase 2
GATA2 GATA binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HES1 hes family bHLH transcription factor 1
HOXA10 homeobox A10
IGFBP6 insulin-like growth factor binding protein 6
KRT7 keratin 7, type II
LMNB1 lamin B1
LY75 lymphocyte antigen 75
MEIS1 Meis homeobox 1
MGLL monoglyceride lipase
NFIB nuclear factor I/B
OLFM4 olfactomedin 4
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REG3A regenerating islet-derived 3 alpha
RELN reelin
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TESC tescalcin
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TNS3 tensin 3
TRIM14 tripartite motif containing 14
TSPAN8 tetraspanin 8
ZNF185 zinc finger protein 185 (LIM domain)
Funding