BRD-K86761848_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

188 genes differentially expressed following the BRD-K86761848_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADM adrenomedullin
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM13A family with sequence similarity 13, member A
FHL2 four and a half LIM domains 2
FLRT3 fibronectin leucine rich transmembrane protein 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GAS1 growth arrest-specific 1
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KIAA1033 KIAA1033
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEB nebulin
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMM2 phosphomannomutase 2
PON3 paraoxonase 3
PPAP2B phosphatidic acid phosphatase type 2B
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS8 protease, serine, 8
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXMP2 peroxisomal membrane protein 2, 22kDa
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK26 serine/threonine protein kinase 26
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
UFM1 ubiquitin-fold modifier 1
USP3 ubiquitin specific peptidase 3
VCAN versican
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALG8 ALG8, alpha-1,3-glucosyltransferase
ASCL1 achaete-scute family bHLH transcription factor 1
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
C1S complement component 1, s subcomponent
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CCNF cyclin F
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CLU clusterin
COL1A2 collagen, type I, alpha 2
COPS7A COP9 signalosome subunit 7A
CPVL carboxypeptidase, vitellogenic-like
CTTN cortactin
CXADR coxsackie virus and adenovirus receptor
DDHD2 DDHD domain containing 2
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EPHB2 EPH receptor B2
ERLIN2 ER lipid raft associated 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLIPR1 GLI pathogenesis-related 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KANK2 KN motif and ankyrin repeat domains 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT13 keratin 13, type I
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LMO2 LIM domain only 2 (rhombotin-like 1)
LYPD1 LY6/PLAUR domain containing 1
METTL7A methyltransferase like 7A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NUAK1 NUAK family, SNF1-like kinase, 1
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPOX protoporphyrinogen oxidase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABGAP1L RAB GTPase activating protein 1-like
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RUNX3 runt-related transcription factor 3
S100A10 S100 calcium binding protein A10
SEPP1 selenoprotein P, plasma, 1
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
TACC1 transforming, acidic coiled-coil containing protein 1
TBC1D16 TBC1 domain family, member 16
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM100 transmembrane protein 100
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)