BRD-K86761848_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K86761848_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA5 annexin A5
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
C6ORF48 chromosome 6 open reading frame 48
CCDC59 coiled-coil domain containing 59
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD99 CD99 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CENPU centromere protein U
CHIC2 cysteine-rich hydrophobic domain 2
CHN2 chimerin 2
CLIC4 chloride intracellular channel 4
COBL cordon-bleu WH2 repeat protein
COL9A3 collagen, type IX, alpha 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
IFI44L interferon-induced protein 44-like
IFRD1 interferon-related developmental regulator 1
JMJD1C jumonji domain containing 1C
JUND jun D proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRCC1 lysine-rich coiled-coil 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NKX3-1 NK3 homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PER2 period circadian clock 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RAB40B RAB40B, member RAS oncogene family
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RYBP RING1 and YY1 binding protein
SC5D sterol-C5-desaturase
SEC31A SEC31 homolog A (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
VCAN versican
WAC WW domain containing adaptor with coiled-coil
XBP1 X-box binding protein 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF451 zinc finger protein 451
ZZZ3 zinc finger, ZZ-type containing 3

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BMP4 bone morphogenetic protein 4
C1ORF116 chromosome 1 open reading frame 116
CAV1 caveolin 1, caveolae protein, 22kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRELD2 cysteine-rich with EGF-like domains 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DES desmin
EMP2 epithelial membrane protein 2
FHOD3 formin homology 2 domain containing 3
FLG filaggrin
FXYD6 FXYD domain containing ion transport regulator 6
GJA1 gap junction protein, alpha 1, 43kDa
GRWD1 glutamate-rich WD repeat containing 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IL13RA2 interleukin 13 receptor, alpha 2
ITGA8 integrin, alpha 8
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
MCM4 minichromosome maintenance complex component 4
METRN meteorin, glial cell differentiation regulator
MMP10 matrix metallopeptidase 10
MRPS16 mitochondrial ribosomal protein S16
NELL2 NEL-like 2 (chicken)
NLRP2 NLR family, pyrin domain containing 2
NXN nucleoredoxin
OBSL1 obscurin-like 1
PCDH7 protocadherin 7
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRUNE2 prune homolog 2 (Drosophila)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSRC1 proline/serine-rich coiled-coil 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
S100A8 S100 calcium binding protein A8
SDC1 syndecan 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLPI secretory leukocyte peptidase inhibitor
SYNM synemin, intermediate filament protein
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN3 tetraspanin 3
TUBA4A tubulin, alpha 4a
VTCN1 V-set domain containing T cell activation inhibitor 1
WFS1 Wolfram syndrome 1 (wolframin)
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1
Funding