BRD-K86797399_pracinostat_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

242 genes differentially expressed following the BRD-K86797399_pracinostat_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AADAC arylacetamide deacetylase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABLIM1 actin binding LIM protein 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG2 BCL2-associated athanogene 2
BTG1 B-cell translocation gene 1, anti-proliferative
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CGA glycoprotein hormones, alpha polypeptide
CHGB chromogranin B
CHIC2 cysteine-rich hydrophobic domain 2
CHMP1B charged multivesicular body protein 1B
CHMP6 charged multivesicular body protein 6
COL21A1 collagen, type XXI, alpha 1
CTH cystathionine gamma-lyase
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSC cathepsin C
CTSW cathepsin W
CYR61 cysteine-rich, angiogenic inducer, 61
DES desmin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DYNLT3 dynein, light chain, Tctex-type 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPHA3 EPH receptor A3
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GSTA4 glutathione S-transferase alpha 4
H2BFS H2B histone family, member S (pseudogene)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOOK2 hook microtubule-tethering protein 2
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPA12A heat shock 70kDa protein 12A
HSPA2 heat shock 70kDa protein 2
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
ISG15 ISG15 ubiquitin-like modifier
ISOC1 isochorismatase domain containing 1
ITM2A integral membrane protein 2A
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
LBH limb bud and heart development
LGMN legumain
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIPA lipase A, lysosomal acid, cholesterol esterase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP1B microtubule-associated protein 1B
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MGST3 microsomal glutathione S-transferase 3
MMD monocyte to macrophage differentiation-associated
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
MYO1B myosin IB
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
OPHN1 oligophrenin 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLS1 plastin 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX2 peroxiredoxin 2
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAD Ras-related associated with diabetes
SCG2 secretogranin II
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPT6 septin 6
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SNAP25 synaptosomal-associated protein, 25kDa
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
SST somatostatin
SYT1 synaptotagmin I
TAC1 tachykinin, precursor 1
TBPL1 TBP-like 1
TBX3 T-box 3
TCTA T-cell leukemia translocation altered
TES testin LIM domain protein
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
TM7SF2 transmembrane 7 superfamily member 2
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACD adrenocortical dysplasia homolog (mouse)
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CA12 carbonic anhydrase XII
CASD1 CAS1 domain containing 1
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CHEK1 checkpoint kinase 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CTSH cathepsin H
CTSS cathepsin S
CXCL9 chemokine (C-X-C motif) ligand 9
CYFIP1 cytoplasmic FMR1 interacting protein 1
DEK DEK proto-oncogene
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ECM1 extracellular matrix protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM57A family with sequence similarity 57, member A
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FST follistatin
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GSAP gamma-secretase activating protein
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA2 high mobility group AT-hook 2
IFI16 interferon, gamma-inducible protein 16
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KLK10 kallikrein-related peptidase 10
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LRRC41 leucine rich repeat containing 41
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICALL1 MICAL-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
NAE1 NEDD8 activating enzyme E1 subunit 1
NDC80 NDC80 kinetochore complex component
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NIP7 NIP7, nucleolar pre-rRNA processing protein
NNT nicotinamide nucleotide transhydrogenase
NREP neuronal regeneration related protein
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
PDHX pyruvate dehydrogenase complex, component X
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSRC1 proline/serine-rich coiled-coil 1
PXDN peroxidasin
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SHCBP1 SHC SH2-domain binding protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMC4 structural maintenance of chromosomes 4
SNX10 sorting nexin 10
SNX7 sorting nexin 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRR3 small proline-rich protein 3
STMN1 stathmin 1
TFDP1 transcription factor Dp-1
TLR4 toll-like receptor 4
TMPO thymopoietin
TNS3 tensin 3
TP53 tumor protein p53
TYMS thymidylate synthetase
VBP1 von Hippel-Lindau binding protein 1
ZNF512B zinc finger protein 512B
Funding