BRD-K86797399_pracinostat_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

284 genes differentially expressed following the BRD-K86797399_pracinostat_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCY9 adenylate cyclase 9
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BLVRB biliverdin reductase B
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CAV2 caveolin 2
CCDC68 coiled-coil domain containing 68
CCDC85B coiled-coil domain containing 85B
CCNG2 cyclin G2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDA cytidine deaminase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLTB clathrin, light chain B
COL21A1 collagen, type XXI, alpha 1
CPD carboxypeptidase D
CRABP1 cellular retinoic acid binding protein 1
CXADR coxsackie virus and adenovirus receptor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ECI2 enoyl-CoA delta isomerase 2
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFHD1 EF-hand domain family, member D1
EFNB2 ephrin-B2
ELOVL4 ELOVL fatty acid elongase 4
ENAH enabled homolog (Drosophila)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F12 coagulation factor XII (Hageman factor)
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FGF9 fibroblast growth factor 9
FRZB frizzled-related protein
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GRK5 G protein-coupled receptor kinase 5
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HAL histidine ammonia-lyase
HEBP1 heme binding protein 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IL13RA2 interleukin 13 receptor, alpha 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JAG1 jagged 1
JARID2 jumonji, AT rich interactive domain 2
KIF2C kinesin family member 2C
KIF5C kinesin family member 5C
KLF10 Kruppel-like factor 10
L1CAM L1 cell adhesion molecule
LBH limb bud and heart development
LGMN legumain
LTA4H leukotriene A4 hydrolase
LTBP1 latent transforming growth factor beta binding protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAPT microtubule-associated protein tau
MEF2C myocyte enhancer factor 2C
METRN meteorin, glial cell differentiation regulator
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYH10 myosin, heavy chain 10, non-muscle
MYO1B myosin IB
NCAM1 neural cell adhesion molecule 1
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NME7 NME/NM23 family member 7
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFML2A olfactomedin-like 2A
OPN3 opsin 3
OSR2 odd-skipped related transciption factor 2
PALLD palladin, cytoskeletal associated protein
PCDH9 protocadherin 9
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PELO pelota homolog (Drosophila)
PHYH phytanoyl-CoA 2-hydroxylase
PID1 phosphotyrosine interaction domain containing 1
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POPDC3 popeye domain containing 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PRR7 proline rich 7 (synaptic)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAP1GAP RAP1 GTPase activating protein
RBKS ribokinase
REEP1 receptor accessory protein 1
RGS10 regulator of G-protein signaling 10
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF44 ring finger protein 44
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAGD Ras-related GTP binding D
RTN2 reticulon 2
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STOM stomatin
SYT17 synaptotagmin XVII
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFF1 trefoil factor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TM4SF20 transmembrane 4 L six family member 20
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WFDC1 WAP four-disulfide core domain 1
ZBTB18 zinc finger and BTB domain containing 18
ZNF277 zinc finger protein 277
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ADAM12 ADAM metallopeptidase domain 12
ADI1 acireductone dioxygenase 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AUTS2 autism susceptibility candidate 2
AVEN apoptosis, caspase activation inhibitor
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNB2 cyclin B2
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD69 CD69 molecule
CFB complement factor B
CFLAR CASP8 and FADD-like apoptosis regulator
CNPY2 canopy FGF signaling regulator 2
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CRELD2 cysteine-rich with EGF-like domains 2
CRISP3 cysteine-rich secretory protein 3
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DPYSL3 dihydropyrimidinase-like 3
EIF5 eukaryotic translation initiation factor 5
EMP3 epithelial membrane protein 3
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FBN1 fibrillin 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GSAP gamma-secretase activating protein
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFRD2 interferon-related developmental regulator 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IRAK1 interleukin-1 receptor-associated kinase 1
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LCN2 lipocalin 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANSC1 MANSC domain containing 1
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
MOK MOK protein kinase
MPZL2 myelin protein zero-like 2
NBN nibrin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNT nicotinamide nucleotide transhydrogenase
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
PDGFC platelet derived growth factor C
PDLIM1 PDZ and LIM domain 1
PGM1 phosphoglucomutase 1
PHF11 PHD finger protein 11
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLTP phospholipid transfer protein
PLXNA2 plexin A2
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRDX4 peroxiredoxin 4
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RGS4 regulator of G-protein signaling 4
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL10 ribosomal protein L10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SENP6 SUMO1/sentrin specific peptidase 6
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SPRY2 sprouty homolog 2 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
VCAM1 vascular cell adhesion molecule 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB38 zinc finger and BTB domain containing 38
Funding