BRD-K86797399_pracinostat_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

366 genes differentially expressed following the BRD-K86797399_pracinostat_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACAA1 acetyl-CoA acyltransferase 1
ADA adenosine deaminase
ADAM9 ADAM metallopeptidase domain 9
ADGRE5 adhesion G protein-coupled receptor E5
AHCYL1 adenosylhomocysteinase-like 1
AIF1 allograft inflammatory factor 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ANK2 ankyrin 2, neuronal
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ASMTL acetylserotonin O-methyltransferase-like
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK5 cyclin-dependent kinase 5
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFD complement factor D (adipsin)
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CHSY1 chondroitin sulfate synthase 1
CIB1 calcium and integrin binding 1 (calmyrin)
CKB creatine kinase, brain
CLIC5 chloride intracellular channel 5
CORO1A coronin, actin binding protein, 1A
CORO1C coronin, actin binding protein, 1C
CPM carboxypeptidase M
CTSA cathepsin A
CYB5A cytochrome b5 type A (microsomal)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMXL2 Dmx-like 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXOSC4 exosome component 4
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FBLN5 fibulin 5
FBXO2 F-box protein 2
FLNA filamin A, alpha
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
GABARAPL2 GABA(A) receptor-associated protein-like 2
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNS glucosamine (N-acetyl)-6-sulfatase
GPM6A glycoprotein M6A
GRK5 G protein-coupled receptor kinase 5
GRN granulin
GSN gelsolin
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDAC1 histone deacetylase 1
HDAC5 histone deacetylase 5
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
INSR insulin receptor
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KIF5C kinesin family member 5C
LAMA5 laminin, alpha 5
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPT microtubule-associated protein tau
MCOLN1 mucolipin 1
MEIS1 Meis homeobox 1
MGST3 microsomal glutathione S-transferase 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MID1 midline 1
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NBPF10 neuroblastoma breakpoint family, member 10
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NDRG3 NDRG family member 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEU1 sialidase 1 (lysosomal sialidase)
NME7 NME/NM23 family member 7
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NRN1 neuritin 1
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG10 paternally expressed 10
PIH1D1 PIH1 domain containing 1
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PNMA1 paraneoplastic Ma antigen 1
POR P450 (cytochrome) oxidoreductase
PRDX1 peroxiredoxin 1
PRSS8 protease, serine, 8
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPRT quinolinate phosphoribosyltransferase
RAB29 RAB29, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOB ras homolog family member B
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNF114 ring finger protein 114
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAS related RAS viral (r-ras) oncogene homolog
RTN2 reticulon 2
RTN3 reticulon 3
RUNX3 runt-related transcription factor 3
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCPEP1 serine carboxypeptidase 1
SERINC3 serine incorporator 3
SFXN3 sideroflexin 3
SIX1 SIX homeobox 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC22A18 solute carrier family 22, member 18
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNN stannin
SNX2 sorting nexin 2
SOBP sine oculis binding protein homolog (Drosophila)
SOX2 SRY (sex determining region Y)-box 2
SPTSSA serine palmitoyltransferase, small subunit A
SQSTM1 sequestosome 1
SRGN serglycin
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
STX1A syntaxin 1A (brain)
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCTA T-cell leukemia translocation altered
TFE3 transcription factor binding to IGHM enhancer 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP1 TIMP metallopeptidase inhibitor 1
TKTL1 transketolase-like 1
TMEM2 transmembrane protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TSPAN3 tetraspanin 3
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDTC1 WD and tetratricopeptide repeats 1
WLS wntless Wnt ligand secretion mediator
ZBTB18 zinc finger and BTB domain containing 18
ZMAT3 zinc finger, matrin-type 3
ZNF277 zinc finger protein 277
ZNF281 zinc finger protein 281

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE41 basic helix-loop-helix family, member e41
BTG3 BTG family, member 3
C1QBP complement component 1, q subcomponent binding protein
C2CD5 C2 calcium-dependent domain containing 5
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CD200 CD200 molecule
CD34 CD34 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD58 CD58 molecule
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CKAP4 cytoskeleton-associated protein 4
CRELD2 cysteine-rich with EGF-like domains 2
DCK deoxycytidine kinase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DPH2 DPH2 homolog (S. cerevisiae)
DSG3 desmoglein 3
DUOX2 dual oxidase 2
DUT deoxyuridine triphosphatase
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FANCL Fanconi anemia, complementation group L
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
FOXM1 forkhead box M1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GATA3 GATA binding protein 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IARS isoleucyl-tRNA synthetase
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLV3-19 immunoglobulin lambda variable 3-19
IL1RN interleukin 1 receptor antagonist
ISOC1 isochorismatase domain containing 1
JCHAIN joining chain of multimeric IgA and IgM
JUP junction plakoglobin
KANK1 KN motif and ankyrin repeat domains 1
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KIF11 kinesin family member 11
KLK10 kallikrein-related peptidase 10
KLK5 kallikrein-related peptidase 5
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MREG melanoregulin
MRPL15 mitochondrial ribosomal protein L15
MRPS35 mitochondrial ribosomal protein S35
MTERF3 mitochondrial transcription termination factor 3
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYO5C myosin VC
MZB1 marginal zone B and B1 cell-specific protein
NBN nibrin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NMU neuromedin U
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PDLIM4 PDZ and LIM domain 4
PHF11 PHD finger protein 11
PLK1 polo-like kinase 1
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPIF peptidylprolyl isomerase F
PRSS23 protease, serine, 23
PTBP3 polypyrimidine tract binding protein 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGS5 regulator of G-protein signaling 5
RPL10 ribosomal protein L10
SERHL2 serine hydrolase-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SMC2 structural maintenance of chromosomes 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRM spermidine synthase
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
TACSTD2 tumor-associated calcium signal transducer 2
TEX10 testis expressed 10
TFF1 trefoil factor 1
THBS2 thrombospondin 2
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TRIM29 tripartite motif containing 29
TRIP13 thyroid hormone receptor interactor 13
TSKU tsukushi, small leucine rich proteoglycan
TYMS thymidylate synthetase
UBA6 ubiquitin-like modifier activating enzyme 6
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VRK2 vaccinia related kinase 2
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZWINT ZW10 interacting kinetochore protein
Funding