BRD-K86899078_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K86899078_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
AXL AXL receptor tyrosine kinase
C6ORF62 chromosome 6 open reading frame 62
CALR calreticulin
CD40 CD40 molecule, TNF receptor superfamily member 5
CEMIP cell migration inducing protein, hyaluronan binding
CLIC4 chloride intracellular channel 4
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
EMX2 empty spiracles homeobox 2
FBP1 fructose-1,6-bisphosphatase 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
GRAMD3 GRAM domain containing 3
GSN gelsolin
HAPLN1 hyaluronan and proteoglycan link protein 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
KRT18 keratin 18, type I
LIMCH1 LIM and calponin homology domains 1
LOC100505650 uncharacterized LOC100505650
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MFSD10 major facilitator superfamily domain containing 10
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NNMT nicotinamide N-methyltransferase
PAM peptidylglycine alpha-amidating monooxygenase
PDIA3 protein disulfide isomerase family A, member 3
PDZK1 PDZ domain containing 1
PXDN peroxidasin
RHOBTB3 Rho-related BTB domain containing 3
S100A4 S100 calcium binding protein A4
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC43A3 solute carrier family 43, member 3
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TP53I3 tumor protein p53 inducible protein 3
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
C7 complement component 7
CCND2 cyclin D2
COL5A2 collagen, type V, alpha 2
FAM129A family with sequence similarity 129, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
GPC3 glypican 3
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
KRT13 keratin 13, type I
MEIS2 Meis homeobox 2
MMP7 matrix metallopeptidase 7
MRPS2 mitochondrial ribosomal protein S2
MSH6 mutS homolog 6
MX2 MX dynamin-like GTPase 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFM1 olfactomedin 1
PTN pleiotrophin
SCML1 sex comb on midleg-like 1 (Drosophila)
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SRPX sushi-repeat containing protein, X-linked