BRD-K87904882_chelerythrine chloride_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K87904882_chelerythrine chloride_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BLNK B-cell linker
BST2 bone marrow stromal cell antigen 2
C5AR1 complement component 5a receptor 1
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLEC11A C-type lectin domain family 11, member A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSTA cystatin A (stefin A)
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
EPRS glutamyl-prolyl-tRNA synthetase
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GARS glycyl-tRNA synthetase
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
JCHAIN joining chain of multimeric IgA and IgM
LCN2 lipocalin 2
LUM lumican
LYN LYN proto-oncogene, Src family tyrosine kinase
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MX1 MX dynamin-like GTPase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OPHN1 oligophrenin 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
POU2AF1 POU class 2 associating factor 1
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RUNX1 runt-related transcription factor 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SIK1 salt-inducible kinase 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TXNRD1 thioredoxin reductase 1
VAMP8 vesicle-associated membrane protein 8
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA

decreased expression

Symbol Name
ALDOC aldolase C, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
ASPH aspartate beta-hydroxylase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
COL2A1 collagen, type II, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
DPYSL3 dihydropyrimidinase-like 3
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
F2R coagulation factor II (thrombin) receptor
FABP7 fatty acid binding protein 7, brain
FGFR3 fibroblast growth factor receptor 3
FSTL1 follistatin-like 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX3 glutathione peroxidase 3
HOPX HOP homeobox
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGF1R insulin-like growth factor 1 receptor
ISOC1 isochorismatase domain containing 1
KIAA0355 KIAA0355
LTBP1 latent transforming growth factor beta binding protein 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFIB nuclear factor I/B
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PDGFC platelet derived growth factor C
PDLIM5 PDZ and LIM domain 5
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPRED2 sprouty-related, EVH1 domain containing 2
TFPI2 tissue factor pathway inhibitor 2
TKTL1 transketolase-like 1
TMEM176A transmembrane protein 176A
TSPAN5 tetraspanin 5
TUBB6 tubulin, beta 6 class V
VCAM1 vascular cell adhesion molecule 1
VIM vimentin
VWF von Willebrand factor
WWTR1 WW domain containing transcription regulator 1