BRD-K87904882_chelerythrine chloride_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K87904882_chelerythrine chloride_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COBL cordon-bleu WH2 repeat protein
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
E2F2 E2F transcription factor 2
EGR1 early growth response 1
FAS Fas cell surface death receptor
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAB2 GRB2-associated binding protein 2
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL6 interleukin 6
LYN LYN proto-oncogene, Src family tyrosine kinase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MZB1 marginal zone B and B1 cell-specific protein
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PYCR1 pyrroline-5-carboxylate reductase 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERTAD2 SERTA domain containing 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TAGLN transgelin
TCTN1 tectonic family member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TXNRD1 thioredoxin reductase 1
WARS tryptophanyl-tRNA synthetase
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
CA12 carbonic anhydrase XII
CCNF cyclin F
CD320 CD320 molecule
CD9 CD9 molecule
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CKS2 CDC28 protein kinase regulatory subunit 2
CLCA2 chloride channel accessory 2
CLTA clathrin, light chain A
COCH cochlin
CXCL14 chemokine (C-X-C motif) ligand 14
DLD dihydrolipoamide dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
EBP emopamil binding protein (sterol isomerase)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNAS GNAS complex locus
HOPX HOP homeobox
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS1 lectin, galactoside-binding, soluble, 1
LRRC17 leucine rich repeat containing 17
MELK maternal embryonic leucine zipper kinase
NPY neuropeptide Y
NREP neuronal regeneration related protein
PBK PDZ binding kinase
PCP4 Purkinje cell protein 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRDX2 peroxiredoxin 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS21 ribosomal protein S21
RPS26 ribosomal protein S26
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
STMN1 stathmin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C