BRD-K87904882_chelerythrine chloride_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K87904882_chelerythrine chloride_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANO10 anoctamin 10
ANXA5 annexin A5
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CARS cysteinyl-tRNA synthetase
CCND1 cyclin D1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CPT1A carnitine palmitoyltransferase 1A (liver)
CRISP3 cysteine-rich secretory protein 3
CST1 cystatin SN
CTSD cathepsin D
CTSL cathepsin L
CYR61 cysteine-rich, angiogenic inducer, 61
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEPTOR DEP domain containing MTOR-interacting protein
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GNAS GNAS complex locus
GOLM1 golgi membrane protein 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IQGAP1 IQ motif containing GTPase activating protein 1
ISCU iron-sulfur cluster assembly enzyme
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
LAMP2 lysosomal-associated membrane protein 2
LMO3 LIM domain only 3 (rhombotin-like 2)
LY75 lymphocyte antigen 75
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OAT ornithine aminotransferase
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
PLXNC1 plexin C1
PYCR1 pyrroline-5-carboxylate reductase 1
RGS5 regulator of G-protein signaling 5
SCG2 secretogranin II
SFN stratifin
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SQSTM1 sequestosome 1
SRRM2 serine/arginine repetitive matrix 2
STC2 stanniocalcin 2
TCEAL4 transcription elongation factor A (SII)-like 4
TFF3 trefoil factor 3 (intestinal)
TPP1 tripeptidyl peptidase I
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VAT1 vesicle amine transport 1
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPO7 exportin 7
YARS tyrosyl-tRNA synthetase
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIRC5 baculoviral IAP repeat containing 5
CCL2 chemokine (C-C motif) ligand 2
CCND3 cyclin D3
CD24 CD24 molecule
CD58 CD58 molecule
CD9 CD9 molecule
CDC42 cell division cycle 42
CLPTM1 cleft lip and palate associated transmembrane protein 1
CLU clusterin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLUL glutamate-ammonia ligase
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HBB hemoglobin, beta
HELLS helicase, lymphoid-specific
HSPA8 heat shock 70kDa protein 8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IGLL1 immunoglobulin lambda-like polypeptide 1
KANK1 KN motif and ankyrin repeat domains 1
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCAM melanoma cell adhesion molecule
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
NDRG2 NDRG family member 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VGLL4 vestigial-like family member 4