BRD-K87904882_chelerythrine chloride_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

251 genes differentially expressed following the BRD-K87904882_chelerythrine chloride_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
ADGRL1 adhesion G protein-coupled receptor L1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA10 annexin A10
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CDV3 CDV3 homolog (mouse)
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
CTSS cathepsin S
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DMD dystrophin
DPYD dihydropyrimidine dehydrogenase
DSE dermatan sulfate epimerase
DUSP10 dual specificity phosphatase 10
EGR1 early growth response 1
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV1 ets variant 1
F12 coagulation factor XII (Hageman factor)
FCGBP Fc fragment of IgG binding protein
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GC group-specific component (vitamin D binding protein)
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GHR growth hormone receptor
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GTPBP8 GTP-binding protein 8 (putative)
HDAC9 histone deacetylase 9
HLA-DMB major histocompatibility complex, class II, DM beta
HOMER1 homer scaffolding protein 1
HOXC10 homeobox C10
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IGFBP6 insulin-like growth factor binding protein 6
IL1R2 interleukin 1 receptor, type II
IL6ST interleukin 6 signal transducer
IRF9 interferon regulatory factor 9
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLF4 Kruppel-like factor 4 (gut)
LCN2 lipocalin 2
LGALS9 lectin, galactoside-binding, soluble, 9
LGMN legumain
LIMA1 LIM domain and actin binding 1
LONP2 lon peptidase 2, peroxisomal
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MCL1 myeloid cell leukemia 1
MDFIC MyoD family inhibitor domain containing
METTL21B methyltransferase like 21B
MFAP5 microfibrillar associated protein 5
MKRN1 makorin ring finger protein 1
MLXIP MLX interacting protein
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MXI1 MAX interactor 1, dimerization protein
OLFM4 olfactomedin 4
PCOLCE procollagen C-endopeptidase enhancer
PFKM phosphofructokinase, muscle
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLAUR plasminogen activator, urokinase receptor
PLBD1 phospholipase B domain containing 1
PLK2 polo-like kinase 2
PLSCR4 phospholipid scramblase 4
PPAP2C phosphatidic acid phosphatase type 2C
PRR7 proline rich 7 (synaptic)
RAB26 RAB26, member RAS oncogene family
RAB29 RAB29, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNF10 ring finger protein 10
RPL31 ribosomal protein L31
SAMHD1 SAM domain and HD domain 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNAI2 snail family zinc finger 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SORBS3 sorbin and SH3 domain containing 3
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
TCTN1 tectonic family member 1
TDO2 tryptophan 2,3-dioxygenase
TM4SF4 transmembrane 4 L six family member 4
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM2 tropomyosin 2 (beta)
TSPAN31 tetraspanin 31
TWIST1 twist family bHLH transcription factor 1
TXNL4B thioredoxin-like 4B
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAV3 vav 3 guanine nucleotide exchange factor
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX15B arachidonate 15-lipoxygenase, type B
ANXA3 annexin A3
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOC1 apolipoprotein C-I
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CD320 CD320 molecule
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLTC clathrin, heavy chain (Hc)
COX7B cytochrome c oxidase subunit VIIb
CRLF1 cytokine receptor-like factor 1
CXADR coxsackie virus and adenovirus receptor
CYB5A cytochrome b5 type A (microsomal)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DPT dermatopontin
EBP emopamil binding protein (sterol isomerase)
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO1 enolase 1, (alpha)
EPN2 epsin 2
ETFB electron-transfer-flavoprotein, beta polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FDPS farnesyl diphosphate synthase
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FTL ferritin, light polypeptide
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GNAS GNAS complex locus
GPI glucose-6-phosphate isomerase
GREM1 gremlin 1, DAN family BMP antagonist
H2AFV H2A histone family, member V
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
IGLL1 immunoglobulin lambda-like polypeptide 1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INHBB inhibin, beta B
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LAMP2 lysosomal-associated membrane protein 2
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGED1 melanoma antigen family D1
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MPZL2 myelin protein zero-like 2
MRPL12 mitochondrial ribosomal protein L12
MRPL57 mitochondrial ribosomal protein L57
MRPS12 mitochondrial ribosomal protein S12
MSMO1 methylsterol monooxygenase 1
MYH10 myosin, heavy chain 10, non-muscle
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NME1 NME/NM23 nucleoside diphosphate kinase 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PFN1 profilin 1
PGK1 phosphoglycerate kinase 1
PNP purine nucleoside phosphorylase
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTK2 protein tyrosine kinase 2
PTMA prothymosin, alpha
PUF60 poly-U binding splicing factor 60KDa
PYCR1 pyrroline-5-carboxylate reductase 1
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RDX radixin
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPN2 ribophorin II
RPS21 ribosomal protein S21
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS9 ribosomal protein S9
S100P S100 calcium binding protein P
SC5D sterol-C5-desaturase
SCAND1 SCAN domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SFTPC surfactant protein C
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SNRPG small nuclear ribonucleoprotein polypeptide G
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SSR4 signal sequence receptor, delta
STOM stomatin
TBCB tubulin folding cofactor B
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
TXNL4A thioredoxin-like 4A
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
VAT1 vesicle amine transport 1
XBP1 X-box binding protein 1
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF512B zinc finger protein 512B