BRD-K87904882_chelerythrine chloride_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K87904882_chelerythrine chloride_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAMDEC1 ADAM-like, decysin 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
CA2 carbonic anhydrase II
CDH17 cadherin 17, LI cadherin (liver-intestine)
CPA3 carboxypeptidase A3 (mast cell)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
EPS8 epidermal growth factor receptor pathway substrate 8
FTH1 ferritin, heavy polypeptide 1
GEM GTP binding protein overexpressed in skeletal muscle
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HGD homogentisate 1,2-dioxygenase
HMGA1 high mobility group AT-hook 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LEPROT leptin receptor overlapping transcript
LHFPL2 lipoma HMGIC fusion partner-like 2
LMNA lamin A/C
LYN LYN proto-oncogene, Src family tyrosine kinase
MET MET proto-oncogene, receptor tyrosine kinase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAMPT nicotinamide phosphoribosyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PIR pirin (iron-binding nuclear protein)
PLTP phospholipid transfer protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
THBS1 thrombospondin 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
XIST X inactive specific transcript (non-protein coding)
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ALDOA aldolase A, fructose-bisphosphate
BPHL biphenyl hydrolase-like (serine hydrolase)
CORO1A coronin, actin binding protein, 1A
CRABP2 cellular retinoic acid binding protein 2
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DMD dystrophin
GPI glucose-6-phosphate isomerase
GSTT1 glutathione S-transferase theta 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGL immunoglobulin lambda locus
MEG3 maternally expressed 3 (non-protein coding)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUSAP1 nucleolar and spindle associated protein 1
PCYOX1 prenylcysteine oxidase 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSENEN presenilin enhancer gamma secretase subunit
PTGER4 prostaglandin E receptor 4 (subtype EP4)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TMPO thymopoietin
TUBB2A tubulin, beta 2A class IIa