BRD-K87904882_chelerythrine chloride_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

138 genes differentially expressed following the BRD-K87904882_chelerythrine chloride_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
BST2 bone marrow stromal cell antigen 2
BTN3A2 butyrophilin, subfamily 3, member A2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL8 chemokine (C-C motif) ligand 8
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSL cathepsin L
CXCL10 chemokine (C-X-C motif) ligand 10
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
ELANE elastase, neutrophil expressed
ELL2 elongation factor, RNA polymerase II, 2
ENO2 enolase 2 (gamma, neuronal)
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1C histone cluster 1, H1c
HIST3H2A histone cluster 3, H2a
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KLF6 Kruppel-like factor 6
LY6E lymphocyte antigen 6 complex, locus E
LYZ lysozyme
MAP2K5 mitogen-activated protein kinase kinase 5
MMP12 matrix metallopeptidase 12
MT2A metallothionein 2A
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PARP12 poly (ADP-ribose) polymerase family, member 12
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PLSCR1 phospholipid scramblase 1
PSAT1 phosphoserine aminotransferase 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RIOK3 RIO kinase 3
RSAD2 radical S-adenosyl methionine domain containing 2
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM22 tripartite motif containing 22
USP18 ubiquitin specific peptidase 18
VEGFA vascular endothelial growth factor A
XAF1 XIAP associated factor 1

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB561 cytochrome b561
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DES desmin
DHRS2 dehydrogenase/reductase (SDR family) member 2
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FHL1 four and a half LIM domains 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
HEBP2 heme binding protein 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F1 nuclear receptor subfamily 2, group F, member 1
PCP4 Purkinje cell protein 4
PLBD1 phospholipase B domain containing 1
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PRPF4 pre-mRNA processing factor 4
PSRC1 proline/serine-rich coiled-coil 1
PXMP2 peroxisomal membrane protein 2, 22kDa
REEP1 receptor accessory protein 1
RPP38 ribonuclease P/MRP 38kDa subunit
SEPW1 selenoprotein W, 1
SORBS1 sorbin and SH3 domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
TFPI2 tissue factor pathway inhibitor 2
TMPO thymopoietin
XIST X inactive specific transcript (non-protein coding)