BRD-K87904882_chelerythrine chloride_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K87904882_chelerythrine chloride_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
AKAP11 A kinase (PRKA) anchor protein 11
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CALB1 calbindin 1, 28kDa
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CST6 cystatin E/M
CSTA cystatin A (stefin A)
CTSB cathepsin B
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DSC2 desmocollin 2
DUSP4 dual specificity phosphatase 4
EHF ets homologous factor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FN1 fibronectin 1
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
GSTP1 glutathione S-transferase pi 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
IL1R1 interleukin 1 receptor, type I
IL32 interleukin 32
KLF5 Kruppel-like factor 5 (intestinal)
KLK10 kallikrein-related peptidase 10
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LCN2 lipocalin 2
MAPT microtubule-associated protein tau
MBNL2 muscleblind-like splicing regulator 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
PLAU plasminogen activator, urokinase
PLSCR3 phospholipid scramblase 3
PPL periplakin
PSAT1 phosphoserine aminotransferase 1
PYGB phosphorylase, glycogen; brain
QPCT glutaminyl-peptide cyclotransferase
RAB25 RAB25, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM30B transmembrane protein 30B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
WARS tryptophanyl-tRNA synthetase
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CSRP2 cysteine and glycine-rich protein 2
EPHA3 EPH receptor A3
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HEBP1 heme binding protein 1
ISOC1 isochorismatase domain containing 1
JMJD6 jumonji domain containing 6
LDHB lactate dehydrogenase B
LMO2 LIM domain only 2 (rhombotin-like 1)
OXTR oxytocin receptor
PDLIM1 PDZ and LIM domain 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PXMP2 peroxisomal membrane protein 2, 22kDa
RBP1 retinol binding protein 1, cellular
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
STMN1 stathmin 1
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
WBP5 WW domain binding protein 5