BRD-K87904882_chelerythrine chloride_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K87904882_chelerythrine chloride_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
BIRC3 baculoviral IAP repeat containing 3
C1QB complement component 1, q subcomponent, B chain
C6ORF62 chromosome 6 open reading frame 62
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK14 cyclin-dependent kinase 14
CFD complement factor D (adipsin)
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO2 enolase 2 (gamma, neuronal)
G0S2 G0/G1 switch 2
GPX2 glutathione peroxidase 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
MMP3 matrix metallopeptidase 3
MNDA myeloid cell nuclear differentiation antigen
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NNMT nicotinamide N-methyltransferase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAP2A RAP2A, member of RAS oncogene family
SLC38A1 solute carrier family 38, member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
STAT1 signal transducer and activator of transcription 1, 91kDa
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN1 tectonic family member 1
TOM1L1 target of myb1 (chicken)-like 1
TOX3 TOX high mobility group box family member 3
TXN thioredoxin
UGCG UDP-glucose ceramide glucosyltransferase
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
BEX1 brain expressed, X-linked 1
CCNI cyclin I
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP2 dual specificity phosphatase 2
EBP emopamil binding protein (sterol isomerase)
EGFL6 EGF-like-domain, multiple 6
GNAS GNAS complex locus
HACD1 3-hydroxyacyl-CoA dehydratase 1
HIST1H2BK histone cluster 1, H2bk
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
KDM5D lysine (K)-specific demethylase 5D
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LY6E lymphocyte antigen 6 complex, locus E
MSMO1 methylsterol monooxygenase 1
PCBP2 poly(rC) binding protein 2
PCP4 Purkinje cell protein 4
PSAP prosaposin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SCG2 secretogranin II
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SMAD7 SMAD family member 7
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN7 tetraspanin 7