BRD-K87904882_chelerythrine chloride_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-K87904882_chelerythrine chloride_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AHNAK AHNAK nucleoprotein
APOLD1 apolipoprotein L domain containing 1
ARC activity-regulated cytoskeleton-associated protein
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAMBI BMP and activin membrane-bound inhibitor
BIRC3 baculoviral IAP repeat containing 3
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY1 cryptochrome circadian clock 1
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CTSL cathepsin L
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
ELL2 elongation factor, RNA polymerase II, 2
FASTKD5 FAST kinase domains 5
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRS2 fibroblast growth factor receptor substrate 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GRWD1 glutamate-rich WD repeat containing 1
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL11 interleukin 11
IL6 interleukin 6
IL6R interleukin 6 receptor
INHBA inhibin, beta A
IRF7 interferon regulatory factor 7
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCTD12 potassium channel tetramerization domain containing 12
KDM5B lysine (K)-specific demethylase 5B
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAL mal, T-cell differentiation protein
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP16 NOP16 nucleolar protein
NPC1 Niemann-Pick disease, type C1
NUP98 nucleoporin 98kDa
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAE1 ribonucleic acid export 1
RBMS1 RNA binding motif, single stranded interacting protein 1
REG1A regenerating islet-derived 1 alpha
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TWIST1 twist family bHLH transcription factor 1
ZBTB10 zinc finger and BTB domain containing 10
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ACSL3 acyl-CoA synthetase long-chain family member 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKAP7 A kinase (PRKA) anchor protein 7
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALOX5 arachidonate 5-lipoxygenase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AUTS2 autism susceptibility candidate 2
BACE2 beta-site APP-cleaving enzyme 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CETN2 centrin, EF-hand protein, 2
CKB creatine kinase, brain
CLEC11A C-type lectin domain family 11, member A
COL4A5 collagen, type IV, alpha 5
CTSG cathepsin G
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCXR dicarbonyl/L-xylulose reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
FADS2 fatty acid desaturase 2
FAM120A family with sequence similarity 120A
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLM1 golgi membrane protein 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HADH hydroxyacyl-CoA dehydrogenase
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KRCC1 lysine-rich coiled-coil 1
LOC100272216 uncharacterized LOC100272216
LOXL1 lysyl oxidase-like 1
MANSC1 MANSC domain containing 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MLPH melanophilin
MPZL2 myelin protein zero-like 2
MYO5C myosin VC
NRGN neurogranin (protein kinase C substrate, RC3)
PAX6 paired box 6
PBX1 pre-B-cell leukemia homeobox 1
PGM1 phosphoglucomutase 1
PPA2 pyrophosphatase (inorganic) 2
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCB protein kinase C, beta
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTCH1 patched 1
RAB40B RAB40B, member RAS oncogene family
RPA3 replication protein A3, 14kDa
SCP2 sterol carrier protein 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM106C transmembrane protein 106C
TMX4 thioredoxin-related transmembrane protein 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN6 tetraspanin 6
WWTR1 WW domain containing transcription regulator 1