BRD-K87909389_alvocidib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

302 genes differentially expressed following the BRD-K87909389_alvocidib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
AREG amphiregulin
ARHGAP25 Rho GTPase activating protein 25
ARHGAP32 Rho GTPase activating protein 32
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
BLNK B-cell linker
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCNA1 cyclin A1
CCRL2 chemokine (C-C motif) receptor-like 2
CD302 CD302 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD84 CD84 molecule
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEP70 centrosomal protein 70kDa
CERS6 ceramide synthase 6
CFD complement factor D (adipsin)
CFH complement factor H
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC7A C-type lectin domain family 7, member A
CLIC2 chloride intracellular channel 2
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CTSK cathepsin K
CTSS cathepsin S
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPT dermatopontin
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
F11R F11 receptor
FBLN1 fibulin 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FLT1 fms-related tyrosine kinase 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FPR3 formyl peptide receptor 3
FRY furry homolog (Drosophila)
FST follistatin
GAGE3 G antigen 3
GLUL glutamate-ammonia ligase
GPC4 glypican 4
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GSN gelsolin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
HCLS1 hematopoietic cell-specific Lyn substrate 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTRA1 HtrA serine peptidase 1
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGL immunoglobulin lambda locus
IGSF6 immunoglobulin superfamily, member 6
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
ISYNA1 inositol-3-phosphate synthase 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITM2A integral membrane protein 2A
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR6 lysophosphatidic acid receptor 6
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MSR1 macrophage scavenger receptor 1
MXRA5 matrix-remodelling associated 5
MYRF myelin regulatory factor
NCF2 neutrophil cytosolic factor 2
NEBL nebulette
NMU neuromedin U
NR4A2 nuclear receptor subfamily 4, group A, member 2
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PARM1 prostate androgen-regulated mucin-like protein 1
PAX6 paired box 6
PCLO piccolo presynaptic cytomatrix protein
PCOLCE procollagen C-endopeptidase enhancer
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PLLP plasmolipin
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PON3 paraoxonase 3
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPT1 palmitoyl-protein thioesterase 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS16 protease, serine, 16 (thymus)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL31 ribosomal protein L31
RSAD2 radical S-adenosyl methionine domain containing 2
S100A8 S100 calcium binding protein A8
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SLAMF8 SLAM family member 8
SOD3 superoxide dismutase 3, extracellular
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SSPN sarcospan
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
SYBU syntabulin (syntaxin-interacting)
TCF4 transcription factor 4
TF transferrin
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM231 transmembrane protein 231
TMEM30B transmembrane protein 30B
TOX thymocyte selection-associated high mobility group box
TPSAB1 tryptase alpha/beta 1
TREM2 triggering receptor expressed on myeloid cells 2
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EMP3 epithelial membrane protein 3
FBL fibrillarin
FHL2 four and a half LIM domains 2
GRSF1 G-rich RNA sequence binding factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
KRT10 keratin 10, type I
LDLR low density lipoprotein receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MRPS2 mitochondrial ribosomal protein S2
MYBPC1 myosin binding protein C, slow type
NKX3-1 NK3 homeobox 1
NNMT nicotinamide N-methyltransferase
NOP56 NOP56 ribonucleoprotein
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PDLIM5 PDZ and LIM domain 5
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RPL36AL ribosomal protein L36a-like
SACS sacsin molecular chaperone
SCAND1 SCAN domain containing 1
SERBP1 SERPINE1 mRNA binding protein 1
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPX2 TPX2, microtubule-associated
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
USP22 ubiquitin specific peptidase 22
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
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