BRD-K87909389_alvocidib_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-K87909389_alvocidib_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AOX1 aldehyde oxidase 1
APCS amyloid P component, serum
AQP1 aquaporin 1 (Colton blood group)
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BAG2 BCL2-associated athanogene 2
BCHE butyrylcholinesterase
BTG2 BTG family, member 2
C7 complement component 7
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CALCA calcitonin-related polypeptide alpha
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CD24 CD24 molecule
CD4 CD4 molecule
CD84 CD84 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CPE carboxypeptidase E
CTTN cortactin
CXCL10 chemokine (C-X-C motif) ligand 10
CYB561 cytochrome b561
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DDHD2 DDHD domain containing 2
DMXL2 Dmx-like 2
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM162A family with sequence similarity 162, member A
FGR FGR proto-oncogene, Src family tyrosine kinase
FMO2 flavin containing monooxygenase 2 (non-functional)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GC group-specific component (vitamin D binding protein)
GLUL glutamate-ammonia ligase
GOLGA8B golgin A8 family, member B
GPM6A glycoprotein M6A
GRB14 growth factor receptor-bound protein 14
GSTM3 glutathione S-transferase mu 3 (brain)
GUSBP3 glucuronidase, beta pseudogene 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HRG histidine-rich glycoprotein
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSDL2 hydroxysteroid dehydrogenase like 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUNB jun B proto-oncogene
KNG1 kininogen 1
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2A2 mannosidase, alpha, class 2A, member 2
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NGRN neugrin, neurite outgrowth associated
NOTCH3 notch 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM1 olfactomedin 1
OVGP1 oviductal glycoprotein 1, 120kDa
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PDE1A phosphodiesterase 1A, calmodulin-dependent
PEX11A peroxisomal biogenesis factor 11 alpha
PLBD1 phospholipase B domain containing 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPT1 palmitoyl-protein thioesterase 1
PTPRD protein tyrosine phosphatase, receptor type, D
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RPL31 ribosomal protein L31
SCD5 stearoyl-CoA desaturase 5
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SH2D1A SH2 domain containing 1A
SHANK2 SH3 and multiple ankyrin repeat domains 2
SST somatostatin
STC1 stanniocalcin 1
STMN2 stathmin 2
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TPMT thiopurine S-methyltransferase
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AGTR1 angiotensin II receptor, type 1
AHNAK2 AHNAK nucleoprotein 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
C1ORF116 chromosome 1 open reading frame 116
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EAPP E2F-associated phosphoprotein
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IRS2 insulin receptor substrate 2
IVNS1ABP influenza virus NS1A binding protein
JMJD6 jumonji domain containing 6
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LMNA lamin A/C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MELK maternal embryonic leucine zipper kinase
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NOP56 NOP56 ribonucleoprotein
NXN nucleoredoxin
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDHX pyruvate dehydrogenase complex, component X
PDPN podoplanin
PFDN4 prefoldin subunit 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
PXDN peroxidasin
RAE1 ribonucleic acid export 1
RIN2 Ras and Rab interactor 2
RPS11 ribosomal protein S11
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX9 SRY (sex determining region Y)-box 9
STOML2 stomatin (EPB72)-like 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TRIM29 tripartite motif containing 29
TUBA4A tubulin, alpha 4a
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP22 ubiquitin specific peptidase 22
WEE1 WEE1 G2 checkpoint kinase
ZFP36L2 ZFP36 ring finger protein-like 2
Funding