BRD-K87909389_alvocidib_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

244 genes differentially expressed following the BRD-K87909389_alvocidib_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANO1 anoctamin 1, calcium activated chloride channel
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ASPN asporin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BLNK B-cell linker
CADM1 cell adhesion molecule 1
CAMP cathelicidin antimicrobial peptide
CD2 CD2 molecule
CD84 CD84 molecule
CD9 CD9 molecule
CERS6 ceramide synthase 6
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLEC7A C-type lectin domain family 7, member A
COL11A1 collagen, type XI, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL4A5 collagen, type IV, alpha 5
CREB1 cAMP responsive element binding protein 1
CTSV cathepsin V
CXADR coxsackie virus and adenovirus receptor
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
F11R F11 receptor
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRY furry homolog (Drosophila)
FYB FYN binding protein
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDE1 glycerophosphodiester phosphodiesterase 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNLY granulysin
GPC4 glypican 4
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IL13RA2 interleukin 13 receptor, alpha 2
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
KIAA0226L KIAA0226-like
KIF5C kinesin family member 5C
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LAMP3 lysosomal-associated membrane protein 3
LGMN legumain
LOC100505650 uncharacterized LOC100505650
LPPR4 lipid phosphate phosphatase-related protein type 4
LST1 leukocyte specific transcript 1
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MBP myelin basic protein
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MXRA7 matrix-remodelling associated 7
NCF2 neutrophil cytosolic factor 2
NKG7 natural killer cell granule protein 7
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP210 nucleoporin 210kDa
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCOLCE2 procollagen C-endopeptidase enhancer 2
PLBD1 phospholipase B domain containing 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLLP plasmolipin
PPT1 palmitoyl-protein thioesterase 1
PRKCI protein kinase C, iota
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB25 RAB25, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RBP4 retinol binding protein 4, plasma
RNF130 ring finger protein 130
RSAD2 radical S-adenosyl methionine domain containing 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPT6 septin 6
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLIT2 slit homolog 2 (Drosophila)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX17 SRY (sex determining region Y)-box 17
SPON1 spondin 1, extracellular matrix protein
STAP2 signal transducing adaptor family member 2
STC1 stanniocalcin 1
STXBP2 syntaxin binding protein 2
SYNGR2 synaptogyrin 2
TGFB1 transforming growth factor, beta 1
TIMP3 TIMP metallopeptidase inhibitor 3
TPD52 tumor protein D52
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
UGCG UDP-glucose ceramide glucosyltransferase
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLVRA biliverdin reductase A
BTG1 B-cell translocation gene 1, anti-proliferative
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CLTA clathrin, light chain A
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP22 dual specificity phosphatase 22
DUSP5 dual specificity phosphatase 5
EFS embryonal Fyn-associated substrate
FOSL1 FOS-like antigen 1
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GLOD4 glyoxalase domain containing 4
GRB10 growth factor receptor-bound protein 10
GUSBP11 glucuronidase, beta pseudogene 11
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IER5 immediate early response 5
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
JAK1 Janus kinase 1
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LBR lamin B receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSMB microseminoprotein, beta-
MYBPC1 myosin binding protein C, slow type
MYO10 myosin X
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PSD3 pleckstrin and Sec7 domain containing 3
PTTG1 pituitary tumor-transforming 1
PTX3 pentraxin 3, long
RAE1 ribonucleic acid export 1
RIN2 Ras and Rab interactor 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAND1 SCAN domain containing 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPX2 TPX2, microtubule-associated
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
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