BRD-K87909389_alvocidib_LNCAP_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K87909389_alvocidib_LNCAP_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
AKAP7 A kinase (PRKA) anchor protein 7
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AREG amphiregulin
BCHE butyrylcholinesterase
C7 complement component 7
CD9 CD9 molecule
COL9A3 collagen, type IX, alpha 3
CPVL carboxypeptidase, vitellogenic-like
CYFIP2 cytoplasmic FMR1 interacting protein 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBA inhibin, beta A
KDM3A lysine (K)-specific demethylase 3A
LAMA3 laminin, alpha 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MPP1 membrane protein, palmitoylated 1, 55kDa
MUC1 mucin 1, cell surface associated
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PLAT plasminogen activator, tissue
PPOX protoporphyrinogen oxidase
PRDX2 peroxiredoxin 2
PRKCH protein kinase C, eta
QPCT glutaminyl-peptide cyclotransferase
RGS5 regulator of G-protein signaling 5
RRAD Ras-related associated with diabetes
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFRP1 secreted frizzled-related protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCF4 transcription factor 4
THSD7A thrombospondin, type I, domain containing 7A
TMEM110 transmembrane protein 110
TRIB2 tribbles pseudokinase 2

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
AIM2 absent in melanoma 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN2AIP CDKN2A interacting protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CELF2 CUGBP, Elav-like family member 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPT dermatopontin
EIF5 eukaryotic translation initiation factor 5
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP6 insulin-like growth factor binding protein 6
JUND jun D proto-oncogene
KEAP1 kelch-like ECH-associated protein 1
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MIS12 MIS12 kinetochore complex component
MSL2 male-specific lethal 2 homolog (Drosophila)
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRN1 neuritin 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRR15L proline rich 15-like
PTPRO protein tyrosine phosphatase, receptor type, O
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SOX9 SRY (sex determining region Y)-box 9
SPATA2 spermatogenesis associated 2
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TOB2 transducer of ERBB2, 2
TRIM36 tripartite motif containing 36
TWIST1 twist family bHLH transcription factor 1
TXNL4B thioredoxin-like 4B
WEE1 WEE1 G2 checkpoint kinase
ZCCHC8 zinc finger, CCHC domain containing 8
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
ZNF232 zinc finger protein 232
Funding