BRD-K87909389_alvocidib_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K87909389_alvocidib_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
ADD3 adducin 3 (gamma)
ADGRL4 adhesion G protein-coupled receptor L4
AGR2 anterior gradient 2
BBX bobby sox homolog (Drosophila)
BEX1 brain expressed, X-linked 1
BGN biglycan
CCDC53 coiled-coil domain containing 53
CD36 CD36 molecule (thrombospondin receptor)
CFD complement factor D (adipsin)
CHI3L2 chitinase 3-like 2
CLEC11A C-type lectin domain family 11, member A
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CRELD2 cysteine-rich with EGF-like domains 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FABP4 fatty acid binding protein 4, adipocyte
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLT1 fms-related tyrosine kinase 1
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
KIF5C kinesin family member 5C
LAGE3 L antigen family, member 3
LRRC15 leucine rich repeat containing 15
LTBP1 latent transforming growth factor beta binding protein 1
LTBP3 latent transforming growth factor beta binding protein 3
MAGEA3 melanoma antigen family A3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NPDC1 neural proliferation, differentiation and control, 1
NRCAM neuronal cell adhesion molecule
NTS neurotensin
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDIA4 protein disulfide isomerase family A, member 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PLS3 plastin 3
PODXL podocalyxin-like
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PYCARD PYD and CARD domain containing
RAP2A RAP2A, member of RAS oncogene family
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RSU1 Ras suppressor protein 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SYT1 synaptotagmin I
TMEM45A transmembrane protein 45A
TNNC1 troponin C type 1 (slow)
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
VWF von Willebrand factor
WIF1 WNT inhibitory factor 1
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADRB2 adrenoceptor beta 2, surface
ALB albumin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
APOE apolipoprotein E
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCLRE1C DNA cross-link repair 1C
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EED embryonic ectoderm development
EGR1 early growth response 1
EGR2 early growth response 2
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV5 ets variant 5
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FASTKD5 FAST kinase domains 5
FGL2 fibrinogen-like 2
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HNMT histamine N-methyltransferase
HOXA5 homeobox A5
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
KYNU kynureninase
LGALS1 lectin, galactoside-binding, soluble, 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MGLL monoglyceride lipase
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
PDZK1IP1 PDZK1 interacting protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PNMA1 paraneoplastic Ma antigen 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RNF19B ring finger protein 19B
RPP38 ribonuclease P/MRP 38kDa subunit
S100A2 S100 calcium binding protein A2
SATB2 SATB homeobox 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMAD7 SMAD family member 7
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLK2 tousled-like kinase 2
TMEM176B transmembrane protein 176B
TSC22D2 TSC22 domain family, member 2
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
USP1 ubiquitin specific peptidase 1
USP6NL USP6 N-terminal like
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
Funding