BRD-K87909389_alvocidib_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-K87909389_alvocidib_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL2 adhesion G protein-coupled receptor L2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASRGL1 asparaginase like 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCHE butyrylcholinesterase
CD14 CD14 molecule
CD200 CD200 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CECR1 cat eye syndrome chromosome region, candidate 1
CFI complement factor I
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CSF3R colony stimulating factor 3 receptor (granulocyte)
CXCL5 chemokine (C-X-C motif) ligand 5
CYBB cytochrome b-245, beta polypeptide
DIO2 deiodinase, iodothyronine, type II
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DLK1 delta-like 1 homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
FMOD fibromodulin
GPC4 glypican 4
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
HAMP hepcidin antimicrobial peptide
HAPLN1 hyaluronan and proteoglycan link protein 1
HBB hemoglobin, beta
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRF8 interferon regulatory factor 8
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0226L KIAA0226-like
LAMC1 laminin, gamma 1 (formerly LAMB2)
LIMA1 LIM domain and actin binding 1
LIMCH1 LIM and calponin homology domains 1
LITAF lipopolysaccharide-induced TNF factor
LTBP3 latent transforming growth factor beta binding protein 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MFAP5 microfibrillar associated protein 5
MMP7 matrix metallopeptidase 7
MNDA myeloid cell nuclear differentiation antigen
NREP neuronal regeneration related protein
OSBPL9 oxysterol binding protein-like 9
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PDE1A phosphodiesterase 1A, calmodulin-dependent
PEG3 paternally expressed 3
PKP4 plakophilin 4
PLS3 plastin 3
POSTN periostin, osteoblast specific factor
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
STS steroid sulfatase (microsomal), isozyme S
THBS2 thrombospondin 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN12 tetraspanin 12
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican

decreased expression

Symbol Name
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AURKA aurora kinase A
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL10 B-cell CLL/lymphoma 10
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BTG1 B-cell translocation gene 1, anti-proliferative
CCNE2 cyclin E2
CCNF cyclin F
CCNL1 cyclin L1
CD9 CD9 molecule
CD99 CD99 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD1 chromodomain helicase DNA binding protein 1
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF5 eukaryotic translation initiation factor 5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FOXD1 forkhead box D1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GGNBP2 gametogenetin binding protein 2
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA1 homeobox A1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KYNU kynureninase
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPP38 ribonuclease P/MRP 38kDa subunit
SCAF8 SR-related CTD-associated factor 8
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SNRK SNF related kinase
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TBX2 T-box 2
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB1 transducer of ERBB2, 1
TSC22D2 TSC22 domain family, member 2
UPP1 uridine phosphorylase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
Funding