BRD-K87909389_alvocidib_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K87909389_alvocidib_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP10 A kinase (PRKA) anchor protein 10
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
BEX4 brain expressed, X-linked 4
CALB1 calbindin 1, 28kDa
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC92 coiled-coil domain containing 92
CD163 CD163 molecule
CIAPIN1 cytokine induced apoptosis inhibitor 1
COG2 component of oligomeric golgi complex 2
CPB1 carboxypeptidase B1 (tissue)
CRYAB crystallin, alpha B
CSNK1D casein kinase 1, delta
CTSC cathepsin C
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCLK1 doublecortin-like kinase 1
DENND1B DENN/MADD domain containing 1B
DLX2 distal-less homeobox 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EMX2 empty spiracles homeobox 2
FOLR1 folate receptor 1 (adult)
GATA6 GATA binding protein 6
GHITM growth hormone inducible transmembrane protein
GSPT2 G1 to S phase transition 2
GSTP1 glutathione S-transferase pi 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IRS2 insulin receptor substrate 2
KCTD12 potassium channel tetramerization domain containing 12
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KLF4 Kruppel-like factor 4 (gut)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFAP5 microfibrillar associated protein 5
MRPS30 mitochondrial ribosomal protein S30
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1E metallothionein 1E
MXRA5 matrix-remodelling associated 5
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
RAB38 RAB38, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGCE sarcoglycan, epsilon
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI2 tissue factor pathway inhibitor 2
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM45A transmembrane protein 45A
TNXB tenascin XB
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
ACADVL acyl-CoA dehydrogenase, very long chain
ACPP acid phosphatase, prostate
ACSL5 acyl-CoA synthetase long-chain family member 5
ADI1 acireductone dioxygenase 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLMH bleomycin hydrolase
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNG1 cyclin G1
CD36 CD36 molecule (thrombospondin receptor)
CFI complement factor I
CLU clusterin
COL8A2 collagen, type VIII, alpha 2
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CYBA cytochrome b-245, alpha polypeptide
DCN decorin
DUT deoxyuridine triphosphatase
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EDNRB endothelin receptor type B
EFHD1 EF-hand domain family, member D1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FKBP11 FK506 binding protein 11, 19 kDa
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GBP1 guanylate binding protein 1, interferon-inducible
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRAMD3 GRAM domain containing 3
H2AFX H2A histone family, member X
HCP5 HLA complex P5 (non-protein coding)
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HN1 hematological and neurological expressed 1
HPSE heparanase
HSPB1 heat shock 27kDa protein 1
KLK6 kallikrein-related peptidase 6
KRT5 keratin 5, type II
LIG1 ligase I, DNA, ATP-dependent
LOXL2 lysyl oxidase-like 2
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPT microtubule-associated protein tau
MEIS2 Meis homeobox 2
MPZL2 myelin protein zero-like 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NCAPD3 non-SMC condensin II complex, subunit D3
NELL2 NEL-like 2 (chicken)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPY neuropeptide Y
PADI2 peptidyl arginine deiminase, type II
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PPAP2C phosphatidic acid phosphatase type 2C
PPIB peptidylprolyl isomerase B (cyclophilin B)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
RSRP1 arginine/serine-rich protein 1
SCG2 secretogranin II
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFN stratifin
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMC4 structural maintenance of chromosomes 4
SMYD2 SET and MYND domain containing 2
SNAP25 synaptosomal-associated protein, 25kDa
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
STEAP3 STEAP family member 3, metalloreductase
STMN1 stathmin 1
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
TM4SF1 transmembrane 4 L six family member 1
TMEM50A transmembrane protein 50A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM2 tropomyosin 2 (beta)
TTC39A tetratricopeptide repeat domain 39A
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
XBP1 X-box binding protein 1
Funding