| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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244 genes differentially expressed following the BRD-K87909389_alvocidib_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 |
| ACOT13 | acyl-CoA thioesterase 13 |
| ADA | adenosine deaminase |
| ADD3 | adducin 3 (gamma) |
| AHSG | alpha-2-HS-glycoprotein |
| AIF1 | allograft inflammatory factor 1 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 |
| ANKRD36B | ankyrin repeat domain 36B |
| ANPEP | alanyl (membrane) aminopeptidase |
| ANXA1 | annexin A1 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit |
| APOA2 | apolipoprotein A-II |
| APOB | apolipoprotein B |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta |
| ATF3 | activating transcription factor 3 |
| ATHL1 | ATH1, acid trehalase-like 1 (yeast) |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 |
| AUTS2 | autism susceptibility candidate 2 |
| BAG2 | BCL2-associated athanogene 2 |
| BID | BH3 interacting domain death agonist |
| CADM1 | cell adhesion molecule 1 |
| CAPG | capping protein (actin filament), gelsolin-like |
| CAV2 | caveolin 2 |
| CCL20 | chemokine (C-C motif) ligand 20 |
| CCL5 | chemokine (C-C motif) ligand 5 |
| CD3D | CD3d molecule, delta (CD3-TCR complex) |
| CELF2 | CUGBP, Elav-like family member 2 |
| CEP70 | centrosomal protein 70kDa |
| CFB | complement factor B |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) |
| COL1A2 | collagen, type I, alpha 2 |
| COLEC12 | collectin sub-family member 12 |
| CTGF | connective tissue growth factor |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 |
| CTSV | cathepsin V |
| CYBA | cytochrome b-245, alpha polypeptide |
| DEPTOR | DEP domain containing MTOR-interacting protein |
| DSP | desmoplakin |
| DUSP1 | dual specificity phosphatase 1 |
| DUSP6 | dual specificity phosphatase 6 |
| EGR1 | early growth response 1 |
| EIF5A | eukaryotic translation initiation factor 5A |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 |
| FAM129A | family with sequence similarity 129, member A |
| FAM46A | family with sequence similarity 46, member A |
| FAM8A1 | family with sequence similarity 8, member A1 |
| FHL1 | four and a half LIM domains 1 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B |
| FOXC1 | forkhead box C1 |
| FST | follistatin |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 |
| GPC3 | glypican 3 |
| GPX3 | glutathione peroxidase 3 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 |
| HP | haptoglobin |
| IDO1 | indoleamine 2,3-dioxygenase 1 |
| IFITM1 | interferon induced transmembrane protein 1 |
| IFITM2 | interferon induced transmembrane protein 2 |
| IFRD2 | interferon-related developmental regulator 2 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa |
| IGFBP7 | insulin-like growth factor binding protein 7 |
| IL2RG | interleukin 2 receptor, gamma |
| IRS1 | insulin receptor substrate 1 |
| ITGAV | integrin, alpha V |
| ITM2A | integral membrane protein 2A |
| JUN | jun proto-oncogene |
| KLF9 | Kruppel-like factor 9 |
| LAMP3 | lysosomal-associated membrane protein 3 |
| LCN2 | lipocalin 2 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 |
| MARCH6 | membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase |
| MCFD2 | multiple coagulation factor deficiency 2 |
| MEF2C | myocyte enhancer factor 2C |
| MET | MET proto-oncogene, receptor tyrosine kinase |
| MFAP5 | microfibrillar associated protein 5 |
| MGP | matrix Gla protein |
| MSN | moesin |
| MT1F | metallothionein 1F |
| MXI1 | MAX interactor 1, dimerization protein |
| MXRA5 | matrix-remodelling associated 5 |
| MXRA7 | matrix-remodelling associated 7 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 |
| OLFM1 | olfactomedin 1 |
| OSMR | oncostatin M receptor |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 |
| PDLIM1 | PDZ and LIM domain 1 |
| PER1 | period circadian clock 1 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 |
| PLS1 | plastin 1 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
| PTN | pleiotrophin |
| PVALB | parvalbumin |
| RBP1 | retinol binding protein 1, cellular |
| RBP4 | retinol binding protein 4, plasma |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 |
| SMC1A | structural maintenance of chromosomes 1A |
| SOCS2 | suppressor of cytokine signaling 2 |
| SRPR | signal recognition particle receptor (docking protein) |
| STC1 | stanniocalcin 1 |
| TFPI2 | tissue factor pathway inhibitor 2 |
| THBS4 | thrombospondin 4 |
| TLE2 | transducin-like enhancer of split 2 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 |
| TNNT1 | troponin T type 1 (skeletal, slow) |
| TRBC1 | T cell receptor beta constant 1 |
| TTC3 | tetratricopeptide repeat domain 3 |
| TXNIP | thioredoxin interacting protein |
| TYROBP | TYRO protein tyrosine kinase binding protein |
| VWA5A | von Willebrand factor A domain containing 5A |
| WFDC2 | WAP four-disulfide core domain 2 |
| WWTR1 | WW domain containing transcription regulator 1 |
| XIST | X inactive specific transcript (non-protein coding) |
| YPEL5 | yippee-like 5 (Drosophila) |
| ZIC1 | Zic family member 1 |
| ZNF331 | zinc finger protein 331 |
| ZNF91 | zinc finger protein 91 |
| Symbol | Name |
|---|---|
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 |
| BLCAP | bladder cancer associated protein |
| BLMH | bleomycin hydrolase |
| C2CD5 | C2 calcium-dependent domain containing 5 |
| CA2 | carbonic anhydrase II |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
| CALML3 | calmodulin-like 3 |
| CASC3 | cancer susceptibility candidate 3 |
| CCDC47 | coiled-coil domain containing 47 |
| CCNA2 | cyclin A2 |
| CDC20 | cell division cycle 20 |
| CDK1 | cyclin-dependent kinase 1 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B |
| CLGN | calmegin |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) |
| CSTF1 | cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa |
| CXCL12 | chemokine (C-X-C motif) ligand 12 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) |
| DCK | deoxycytidine kinase |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| DHCR24 | 24-dehydrocholesterol reductase |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked |
| EXT1 | exostosin glycosyltransferase 1 |
| FAM69A | family with sequence similarity 69, member A |
| FGFR2 | fibroblast growth factor receptor 2 |
| GCH1 | GTP cyclohydrolase 1 |
| GDI2 | GDP dissociation inhibitor 2 |
| GPX2 | glutathione peroxidase 2 |
| H2AFZ | H2A histone family, member Z |
| HK1 | hexokinase 1 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
| HSPA1A | heat shock 70kDa protein 1A |
| HSPA8 | heat shock 70kDa protein 8 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 |
| ICMT | isoprenylcysteine carboxyl methyltransferase |
| INHBB | inhibin, beta B |
| JCHAIN | joining chain of multimeric IgA and IgM |
| JMJD6 | jumonji domain containing 6 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
| KRT14 | keratin 14, type I |
| KRT15 | keratin 15, type I |
| KRT23 | keratin 23, type I |
| KRT81 | keratin 81, type II |
| LBR | lamin B receptor |
| LGALS4 | lectin, galactoside-binding, soluble, 4 |
| LIMCH1 | LIM and calponin homology domains 1 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 |
| MAGEA3 | melanoma antigen family A3 |
| MALT1 | MALT1 paracaspase |
| MED24 | mediator complex subunit 24 |
| MMP11 | matrix metallopeptidase 11 |
| MSL1 | male-specific lethal 1 homolog (Drosophila) |
| MSMB | microseminoprotein, beta- |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit |
| NET1 | neuroepithelial cell transforming 1 |
| NKX3-1 | NK3 homeobox 1 |
| NPY1R | neuropeptide Y receptor Y1 |
| OPN3 | opsin 3 |
| PBX1 | pre-B-cell leukemia homeobox 1 |
| PCNA | proliferating cell nuclear antigen |
| PNP | purine nucleoside phosphorylase |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 |
| RAB22A | RAB22A, member RAS oncogene family |
| RAE1 | ribonucleic acid export 1 |
| RIN2 | Ras and Rab interactor 2 |
| RNPS1 | RNA binding protein S1, serine-rich domain |
| RPL22 | ribosomal protein L22 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 |
| RRBP1 | ribosome binding protein 1 |
| RRM2 | ribonucleotide reductase M2 |
| RTN1 | reticulon 1 |
| RYBP | RING1 and YY1 binding protein |
| SCAND1 | SCAN domain containing 1 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 |
| SLPI | secretory leukocyte peptidase inhibitor |
| SMC4 | structural maintenance of chromosomes 4 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 |
| SRSF5 | serine/arginine-rich splicing factor 5 |
| ST7 | suppression of tumorigenicity 7 |
| STAU1 | staufen double-stranded RNA binding protein 1 |
| TDO2 | tryptophan 2,3-dioxygenase |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) |
| TM9SF3 | transmembrane 9 superfamily member 3 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| TRIB3 | tribbles pseudokinase 3 |
| TXLNA | taxilin alpha |
| TXNRD1 | thioredoxin reductase 1 |
| TYMS | thymidylate synthetase |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UBE2I | ubiquitin-conjugating enzyme E2I |
| UBE3C | ubiquitin protein ligase E3C |
| USP22 | ubiquitin specific peptidase 22 |
| VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C |
| WIPF2 | WAS/WASL interacting protein family, member 2 |
| XBP1 | X-box binding protein 1 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta |
| ZMIZ1 | zinc finger, MIZ-type containing 1 |
| ZNF217 | zinc finger protein 217 |
| ZWINT | ZW10 interacting kinetochore protein |
