BRD-K87909389_alvocidib_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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104 genes differentially expressed following the BRD-K87909389_alvocidib_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
ADRB2 adrenoceptor beta 2, surface
AIF1 allograft inflammatory factor 1
ALCAM activated leukocyte cell adhesion molecule
ANKRD36B ankyrin repeat domain 36B
APLP2 amyloid beta (A4) precursor-like protein 2
BPHL biphenyl hydrolase-like (serine hydrolase)
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COLEC12 collectin sub-family member 12
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
GOLGA4 golgin A4
GPX1 glutathione peroxidase 1
HIST1H1C histone cluster 1, H1c
HIST1H3H histone cluster 1, H3h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ITGA6 integrin, alpha 6
KIAA0226L KIAA0226-like
LAMC1 laminin, gamma 1 (formerly LAMB2)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAOA monoamine oxidase A
MARCO macrophage receptor with collagenous structure
MYO6 myosin VI
NT5DC2 5'-nucleotidase domain containing 2
NTS neurotensin
OSBPL10 oxysterol binding protein-like 10
PLEK pleckstrin
PRDX2 peroxiredoxin 2
PTPRC protein tyrosine phosphatase, receptor type, C
SFTPB surfactant protein B
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TES testin LIM domain protein
TIMP3 TIMP metallopeptidase inhibitor 3
TPM2 tropomyosin 2 (beta)
TPM4 tropomyosin 4
VAMP8 vesicle-associated membrane protein 8
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTA2 actin, alpha 2, smooth muscle, aorta
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ASF1A anti-silencing function 1A histone chaperone
BCL7B B-cell CLL/lymphoma 7B
C1S complement component 1, s subcomponent
CANT1 calcium activated nucleotidase 1
CCNF cyclin F
CDCA4 cell division cycle associated 4
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CLU clusterin
COG2 component of oligomeric golgi complex 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAS Fas cell surface death receptor
FBXL14 F-box and leucine-rich repeat protein 14
FGFR2 fibroblast growth factor receptor 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IL1R2 interleukin 1 receptor, type II
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JMJD6 jumonji domain containing 6
KRT23 keratin 23, type I
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NXT1 nuclear transport factor 2-like export factor 1
PROS1 protein S (alpha)
RAB20 RAB20, member RAS oncogene family
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SORBS2 sorbin and SH3 domain containing 2
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
STK17A serine/threonine kinase 17a
STXBP6 syntaxin binding protein 6 (amisyn)
TGIF1 TGFB-induced factor homeobox 1
TMEM185B transmembrane protein 185B
TRIB3 tribbles pseudokinase 3
USP1 ubiquitin specific peptidase 1
VGLL1 vestigial-like family member 1
XBP1 X-box binding protein 1
ZNF22 zinc finger protein 22